Document Detail

Valproic acid in the treatment of Sydenham chorea.
MedLine Citation:
PMID:  3939747     Owner:  NLM     Status:  MEDLINE    
Severe cases of Sydenham chorea are still difficult to manage because optimal therapy has not been found. In this report severe chorea responded to valproic acid therapy after trials with diazepam and haloperidol had failed. The literature is reviewed and the possible mechanism of action of valproate in this movement disorder is discussed. Valproic acid is proposed as an effective treatment for severe cases of Sydenham chorea.
L A Alvarez; G Novak
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  1     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1985 Sep-Oct
Date Detail:
Created Date:  1989-06-23     Completed Date:  1989-06-23     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-9     Citation Subset:  IM    
Department of Neurology, Montefiore Medical Center, Bronx, NY 10467.
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MeSH Terms
Chorea / drug therapy*
Diazepam / therapeutic use
Haloperidol / therapeutic use
Valproic Acid / therapeutic use*
Reg. No./Substance:
439-14-5/Diazepam; 52-86-8/Haloperidol; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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