Document Detail

Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review.
MedLine Citation:
PMID:  23976844     Owner:  NLM     Status:  In-Data-Review    
A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented.
Hai-Fei Chen; Li-Ping Xu; Zhi-Yong Luo; Zi-Qiang Yu; Zheng-Yang Li; Qing-Ya Cui; Long-Mei Qin; Yong-Ya Ren; Hong-Shi Shen; Jie-Qing Tang; Ling-Juan Jin; Jing-Jing Zhu; Jing Wang; Ke-Yuan Wang; Tian-Qin Wu; Zhao-Yue Wang
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Publication Detail:
Type:  Journal Article     Date:  2013-08-13
Journal Detail:
Title:  Drug design, development and therapy     Volume:  7     ISSN:  1177-8881     ISO Abbreviation:  Drug Des Devel Ther     Publication Date:  2013  
Date Detail:
Created Date:  2013-08-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475745     Medline TA:  Drug Des Devel Ther     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  767-70     Citation Subset:  IM    
Department of Hematology, 100th Hospital of People's Liberation Army, Suzhou, People's Republic of China ; Jiangsu institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
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