| Valproic acid attenuates proteinuria and kidney injury. | |
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MedLine Citation:
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PMID: 21868496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibitors of histone deacetylase (HDAC) have anti-inflammatory and antifibrotic effects in several organs and tissues, but their effect on the progression of renal disease is unknown. Here, we studied the effect of valproic acid in adriamycin-induced nephropathy in mice. Administration of valproic acid before kidney injury prevented the development of proteinuria and the onset of glomerulosclerosis. Even after postponing treatment until the peak of adriamycin-induced proteinuria, valproic acid rapidly decreased the quantity of proteinuria and attenuated the progression of renal disease. Valproic acid abrogated the decrease in glomerular acetylation observed during adriamycin-induced nephropathy. Furthermore, valproic acid attenuated the significant upregulation of profibrotic and proinflammatory genes, the deposition of collagen, and the infiltration of macrophages into the kidney. Valproic acid decreased glomerular apoptosis and proliferation induced by adriamycin. Ultrastructural studies further supported the protective effect of valproic acid on podocytes in this model. Taken together, these data suggest that HDACs contribute to the pathogenesis of renal disease and that HDAC inhibitors may have therapeutic potential in CKD. |
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Authors:
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Katrien Van Beneden; Caroline Geers; Marina Pauwels; Inge Mannaerts; Dierik Verbeelen; Leo A van Grunsven; Christiane Van den Branden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-08-25 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 22 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-03 Completed Date: 2011-11-21 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1863-75 Citation Subset: IM |
Affiliation:
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Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Kidney Injury
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prevention & control Animals Antibiotics, Antineoplastic Disease Models, Animal Doxorubicin Drug Evaluation, Preclinical Female Glomerulosclerosis, Focal Segmental / chemically induced, drug therapy* Histone Deacetylase Inhibitors / therapeutic use* Mice Mice, Inbred BALB C Proteinuria / prevention & control Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Histone Deacetylase Inhibitors; 23214-92-8/Doxorubicin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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