Document Detail

Valproate teratogenicity and epilepsy syndrome.
MedLine Citation:
PMID:  18557775     Owner:  NLM     Status:  MEDLINE    
Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and medical records, when available, of enrollees in the North American Antiepileptic Drug Pregnancy Registry, classifying reason for treatment as idiopathic generalized epilepsy (IGE), partial epilepsy (PE), nonclassifiable epilepsy (NCE), or not epilepsy (NE). Of 284 VPA-exposed pregnancies, 30 (11.0%) were associated with malformations: IGE = 15/126 (12%), PE = 4/28 (14%), NCE = 9/105 (9%), NE = 2/25 (8%) (p > 0.7 for all comparisons). There was a trend toward increased malformation risk with higher VPA doses (p = 0.07). VPA, and not the underlying genetic syndrome, seems to be associated with the elevated risk for malformations in the drug-exposed fetus.
Edward B Bromfield; Barbara A Dworetzky; Diego F Wyszynski; Caitlin R Smith; Elizabeth J Baldwin; Lewis B Holmes
Related Documents :
19786965 - Maternal overweight before pregnancy and asthma in offspring followed for 8 years.
16537815 - Fetal exposure to 3,4-diaminopyridine in a pregnant woman with congenital myasthenia sy...
10487185 - Malformations in offspring of women with epilepsy: a prospective study.
7746175 - Information on drugs and environmental influences in pregnancy in popular magazines: a ...
8335135 - Erythrocytic ouabain-sensitive sodium efflux rate constant in pregnancy.
8941065 - Premature luteinization during controlled ovarian hyperstimulation for in vitro fertili...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-13
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2122-4     Citation Subset:  IM    
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / etiology*
Age of Onset
Analysis of Variance
Anticonvulsants / adverse effects*
Dose-Response Relationship, Drug
Epilepsy / classification,  drug therapy
Maternal Exposure / adverse effects*
Prenatal Exposure Delayed Effects*
Valproic Acid / adverse effects*
Reg. No./Substance:
0/Anticonvulsants; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Posterior cortex epilepsy secondary to ulegyria: is it a surgically remediable syndrome?
Next Document:  Prognosis after temporal lobe epilepsy surgery: the value of combining predictors.