| Valproate teratogenicity and epilepsy syndrome. | |
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MedLine Citation:
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PMID: 18557775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and medical records, when available, of enrollees in the North American Antiepileptic Drug Pregnancy Registry, classifying reason for treatment as idiopathic generalized epilepsy (IGE), partial epilepsy (PE), nonclassifiable epilepsy (NCE), or not epilepsy (NE). Of 284 VPA-exposed pregnancies, 30 (11.0%) were associated with malformations: IGE = 15/126 (12%), PE = 4/28 (14%), NCE = 9/105 (9%), NE = 2/25 (8%) (p > 0.7 for all comparisons). There was a trend toward increased malformation risk with higher VPA doses (p = 0.07). VPA, and not the underlying genetic syndrome, seems to be associated with the elevated risk for malformations in the drug-exposed fetus. |
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Authors:
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Edward B Bromfield; Barbara A Dworetzky; Diego F Wyszynski; Caitlin R Smith; Elizabeth J Baldwin; Lewis B Holmes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-13 |
Journal Detail:
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Title: Epilepsia Volume: 49 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-03 Completed Date: 2009-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 2122-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ebromfield@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Age of Onset Analysis of Variance Anticonvulsants / adverse effects* Dose-Response Relationship, Drug Epilepsy / classification, drug therapy Female Humans Male Maternal Exposure / adverse effects* Pregnancy Prenatal Exposure Delayed Effects* Questionnaires Registries Valproic Acid / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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