Document Detail


Valproate teratogenicity and epilepsy syndrome.
MedLine Citation:
PMID:  18557775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and medical records, when available, of enrollees in the North American Antiepileptic Drug Pregnancy Registry, classifying reason for treatment as idiopathic generalized epilepsy (IGE), partial epilepsy (PE), nonclassifiable epilepsy (NCE), or not epilepsy (NE). Of 284 VPA-exposed pregnancies, 30 (11.0%) were associated with malformations: IGE = 15/126 (12%), PE = 4/28 (14%), NCE = 9/105 (9%), NE = 2/25 (8%) (p > 0.7 for all comparisons). There was a trend toward increased malformation risk with higher VPA doses (p = 0.07). VPA, and not the underlying genetic syndrome, seems to be associated with the elevated risk for malformations in the drug-exposed fetus.
Authors:
Edward B Bromfield; Barbara A Dworetzky; Diego F Wyszynski; Caitlin R Smith; Elizabeth J Baldwin; Lewis B Holmes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-13
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2122-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ebromfield@partners.org
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Age of Onset
Analysis of Variance
Anticonvulsants / adverse effects*
Dose-Response Relationship, Drug
Epilepsy / classification,  drug therapy
Female
Humans
Male
Maternal Exposure / adverse effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Questionnaires
Registries
Valproic Acid / adverse effects*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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