Document Detail

Valproate monotherapy in partial seizures.
MedLine Citation:
PMID:  3146219     Owner:  NLM     Status:  MEDLINE    
Results of a retrospective study in 30 patients indicate that, contrary to the findings of some earlier studies, valproate monotherapy is highly effective in the treatment of partial seizures, especially those that become secondarily generalized. In 22 of these 30 patients (73 percent), valproate monotherapy either abolished seizures (12 patients) or reduced their frequency by at least 51 percent (10 patients), whereas eight patients experienced minimal or no reduction in seizure frequency. All these patients had previously experienced treatment failure with carbamazepine, phenytoin, or phenobarbital--either alone or combined--because of lack of efficacy or unacceptable side effects. In these patients, failure to have a response to valproate therapy appeared to be related to the type of seizure (simple partial seizures alone/complex partial seizures alone, without secondarily generalized tonic-clonic seizures) and longer duration of uncontrolled seizures. Although these results cannot be generalized to all patients with partial seizures, they do indicate that a double-blind randomized trial of valproate in patients with all types of partial seizures is warranted.
J K Penry; J C Dean
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  84     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1989-03-02     Completed Date:  1989-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14-6     Citation Subset:  AIM; IM    
Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27102.
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MeSH Terms
Child, Preschool
Epilepsies, Partial / drug therapy*
Middle Aged
Retrospective Studies
Valproic Acid / administration & dosage*,  therapeutic use
Reg. No./Substance:
99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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