| Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility. | |
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MedLine Citation:
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PMID: 12196666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay. Generally, only a small proportion of prenatally exposed children are affected. The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome. The risk for recurrence in a subsequent pregnancy may be high and should be taken into account in the counseling of parents and in considering drug treatment. |
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Authors:
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H Malm; E Kajantie; S Kivirikko; H Kääriäinen; M Peippo; M Somer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurology Volume: 59 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-28 Completed Date: 2002-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 630-3 Citation Subset: AIM; IM |
Affiliation:
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Teratology Information Service, Department of Medical Genetics, Family Federation of Finland, Helsinki. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced*
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diagnosis Abnormalities, Multiple / chemically induced*, diagnosis Child Child, Preschool Developmental Disabilities / chemically induced*, diagnosis Epilepsy / drug therapy Face / abnormalities* Female Genetic Predisposition to Disease* Humans Infant Infant, Newborn Male Maternal-Fetal Exchange Pregnancy Pregnancy Complications / drug therapy Syndrome Valproic Acid / adverse effects* |
| Chemical | |
Reg. No./Substance:
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99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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