Document Detail


Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals.
MedLine Citation:
PMID:  22963924     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Valproate is well established in the treatment of epilepsy and psychiatric disorders, yet the main mechanism of action remains to be determined. Here we show that valproate may reduce neurotransmission of the excitatory amino acid, aspartate. By electron microscopic immunogold cytochemistry we demonstrate a 63-68% reduction in the level of aspartate in excitatory nerve terminals at 30min after an acute dose of valproate. The level of glutamate in the same terminals was unchanged by valproate treatment. In inhibitory terminals, valproate caused a 65% decrease in the aspartate level, whereas the GABA level was not significantly changed. In summary, the present study shows that valproate reduces the nerve terminal content of the excitatory neurotransmitter aspartate. This points to a new mechanism of action for valproate: reduced neuronal excitation through reduced aspartergic neurotransmission.
Authors:
Cecilie Morland; Kaja Nordengen; Vidar Gundersen
Related Documents :
1024474 - An attempt at comparing the results of carboxyhaemoglobin level in blood and gasometric...
16805624 - Trimethylamine as a probe molecule to differentiate acid sites in y-fau zeolite: ftir s...
18922984 - Acid-base disturbances in gastrointestinal disease.
12069324 - Lysineurethanedimethacrylate--a novel generation of amino acid based monomers for bone ...
21964384 - Clavulanic acid increases dopamine release in neuronal cells through a mechanism involv...
15850714 - Plasma fatty acids of neonates born to mothers with and without gestational diabetes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Anatomy and the CMBN, University of Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vaccine innovation, translational research and the management of knowledge accumulation.
Next Document:  NEDD9 rs760678 polymorphism and the risk of Alzheimer's disease: A meta-analysis.