Document Detail

Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women?
MedLine Citation:
PMID:  12551733     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Evidence indicates that valproate (VPA) may have an adverse impact on reproductive endocrine and metabolic functions in women with epilepsy. This study explores whether the association of VPA with reproductive endocrine abnormalities is applicable to women with bipolar disorder (BD) or is unique to women with epilepsy. METHODS: Thirty female patients aged 18-40 years with a DSM-IV diagnosis of BD (15 on lithium monotherapy and 15 on VPA monotherapy or VPA in combination with lithium therapy) and 15 with idiopathic generalized epilepsy (IGE) on VPA monotherapy were evaluated for reproductive endocrine functioning and metabolic parameters. RESULTS: The menarche age, mean length of menstrual cycle and mean length of menses were not significantly different between groups. None of the bipolar patients on lithium, three (20%) of the bipolar patients on VPA and seven (47%) of the epileptic patients on VPA reported menstrual disturbances. Hirsutism scores of the epilepsy group were significantly higher than those bipolar women, regardless of treatment. Serum total testosterone levels were significantly higher in patients (both with BD and with IGE) treated with VPA than in those treated with lithium. Serum FSH levels were significantly lower and LH-to-FSH ratio was significantly higher in patients with epilepsy than in patients with BD, regardless of treatment. The weight parameters and lipid values investigated did not differ significantly between the groups. CONCLUSION: The study supports the conclusion that VPA may be associated with menstrual abnormalities and increased total testosterone levels in both bipolar and epileptic patients although women with BD did not show clinical features of hyperandrogenism (menstrual abnormalities, hirsutism and truncal obesity) as did frequently as women with epilepsy.
Fisun Akdeniz; Fatma Taneli; Ayşin Noyan; Zeki Yüncü; Simavi Vahip
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  27     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-28     Completed Date:  2003-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  IM    
Department of Psychiatry, Affective Disorders Unit, Ege University School of Medicine, 35100 Bornova, Izmir, Turkey.
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MeSH Terms
Antimanic Agents / adverse effects*
Bipolar Disorder / drug therapy*
Cross-Sectional Studies
Endocrine System / drug effects
Epilepsy / complications*
Hirsutism / chemically induced
Menstruation Disturbances / chemically induced*
Metabolic Diseases / chemically induced*
Obesity / chemically induced
Risk Factors
Testosterone / blood
Valproic Acid / adverse effects*
Weight Gain
Reg. No./Substance:
0/Antimanic Agents; 58-22-0/Testosterone; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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