| Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727. | |
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MedLine Citation:
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PMID: 15032484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium. |
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Authors:
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Fabrizio Beltrametti; Srdjan Jovetic; Marina Feroggio; Luciano Gastaldo; Enrico Selva; Flavia Marinelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 57 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-03-22 Completed Date: 2004-04-20 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Vicuron Pharmaceuticals Italy S.r.l., Via R. Lepetit, 34, 21040, Gerenzano (Varese) Italy. fbeltrametti@ricuron.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actinobacteria
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metabolism* Anti-Bacterial Agents / biosynthesis*, chemistry Chromatography, High Pressure Liquid Fatty Acids / metabolism Fermentation Glycopeptides* Molecular Structure Teicoplanin / analogs & derivatives Valine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/A 40926; 0/Anti-Bacterial Agents; 0/Fatty Acids; 0/Glycopeptides; 61036-62-2/Teicoplanin; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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