Document Detail

Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.
MedLine Citation:
PMID:  15032484     Owner:  NLM     Status:  MEDLINE    
In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium.
Fabrizio Beltrametti; Srdjan Jovetic; Marina Feroggio; Luciano Gastaldo; Enrico Selva; Flavia Marinelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  57     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-04-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Vicuron Pharmaceuticals Italy S.r.l., Via R. Lepetit, 34, 21040, Gerenzano (Varese) Italy.
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MeSH Terms
Actinobacteria / metabolism*
Anti-Bacterial Agents / biosynthesis*,  chemistry
Chromatography, High Pressure Liquid
Fatty Acids / metabolism
Molecular Structure
Teicoplanin / analogs & derivatives
Valine / metabolism*
Reg. No./Substance:
0/A 40926; 0/Anti-Bacterial Agents; 0/Fatty Acids; 0/Glycopeptides; 61036-62-2/Teicoplanin; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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