Document Detail

Valine, a branched-chain amino Acid, reduced HCV viral load and led to eradication of HCV by interferon therapy in a decompensated cirrhotic patient.
MedLine Citation:
PMID:  23185147     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A decreased serum level of branched-chain amino acid (BCAA) is a distinctive metabolic disorder in patients with liver cirrhosis. Recently, BCAA has been reported to exert various pharmacological activities, and valine, which is a BCAA, has been shown to affect lipid metabolism and the immune system in in vivo experiments. However, the clinical impact of valine supplementation on viral hepatitis C virus (HCV) load has never been reported. Here, we first describe a case of HCV-related advanced liver cirrhosis that was treated by an oral valine agent. The administration of valine resulted in an improvement of fatigue and a reduction in hepatic fibrosis indexes as well as serum α-fetoprotein level. Furthermore, a marked reduction in HCV RNA levels was seen after valine treatment. The patient was then treated by interferon β, resulting in the successful eradication of chronic HCV infection. Thus, valine may be involved in the reduction of HCV viral load and could support a sustained virologic response to interferon therapy.
Takumi Kawaguchi; Takuji Torimura; Akio Takata; Susumu Satomi; Michio Sata
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Publication Detail:
Type:  Journal Article     Date:  2012-10-24
Journal Detail:
Title:  Case reports in gastroenterology     Volume:  6     ISSN:  1662-0631     ISO Abbreviation:  Case Rep Gastroenterol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-11-27     Completed Date:  2012-11-28     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101474819     Medline TA:  Case Rep Gastroenterol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  660-7     Citation Subset:  -    
Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan ; Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan ; Liver Cancer Research Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan.
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