Document Detail


Validity of self-reported data on pregnancies for childhood cancer survivors: a comparison with data from a nationwide population-based registry.
MedLine Citation:
PMID:  23175500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY QUESTION: To what degree do records registered in the Netherlands Perinatal Registry (PRN) agree with self-report in a study questionnaire on pregnancy outcomes in childhood cancer survivors (CCSs)?
SUMMARY ANSWER: This study suggests that self-reported pregnancy outcomes of CCSs agree well with registry data and that outcomes reported by CCSs agree better with registry data than do those of controls.
WHAT IS KNOWN ALREADY: Many studies have shown that childhood cancer treatment may affect fertility outcomes in female CCSs; however, these conclusions were often based on questionnaire data, and it remains unclear whether self-report agrees well with more objective sources of information.
STUDY DESIGN, SIZE, DURATION: In an nationwide cohort study on fertility (inclusion period January 2008 and April 2011, trial number: NTR2922), 1420 CCSs and 354 sibling controls were invited to complete a questionnaire regarding socio-demographic characteristics and reproductive history. In total, 879 CCSs (62%) and 287 controls (81%) returned the questionnaire.
PARTICIPANTS/MATERIALS, SETTING, METHODS: The current validation study compared the agreement between pregnancy outcomes as registered in the PRN and self-reported outcomes in the study questionnaire. A total of 589 pregnancies were reported in CCSs, and 300 pregnancies in sibling controls, of which 524 could be linked to the PRN.
MAIN RESULTS AND THE ROLE OF CHANCE: A high intra-class correlation coefficient (ICC) was found for birthweight (BW) (0.94 and 0.87 for CCSs and controls, respectively). The self-reported BWs tended to be higher than reported in the PRN. For gestational age (GA), the ICC was high for CCSs (0.88), but moderate for controls (0.49). CCSs overestimated GA more often than controls. The Kappa values for method of conception and for method of delivery were moderate to good. Multilevel analyses on the mean difference with regard to BW and GA showed no differences associated with time since pregnancy or educational level.
LIMITATIONS, REASONS FOR CAUTION: Not all pregnancies reported could be linked to the registry data. In addition, the completeness of the PRN could not be assessed precisely, because there is no information on the number of missing records. Finally, for some outcomes there were high proportions of missing values in the PRN registry.
WIDER IMPLICATIONS OF THE FINDINGS: Our study suggests that questionnaires are a reliable method of data collection, and that for most variables, self-report agrees well with registry data.
STUDY FUNDING/COMPETING INTEREST: This work was supported by the Dutch Cancer Society (grant no. VU 2006-3622) and by Foundation Children Cancer Free. None of the authors report a conflict of interest.
TRIAL REGISTRATION NUMBER: NTR2922 http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2922.
Authors:
A Overbeek; M H van den Berg; C W P M Hukkelhoven; L C Kremer; M M van den Heuvel-Eibrink; W J E Tissing; J J Loonen; A B Versluys; D Bresters; G J L Kaspers; C B Lambalk; F E van Leeuwen; E van Dulmen-den Broeder;
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2012-11-21
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  28     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-08-23     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  819-27     Citation Subset:  IM    
Affiliation:
Division of Pediatric Oncology/Hematology, Department of Pediatrics, VU University Medical Center, PO Box 7057, Amsterdam 1000 MB, The Netherlands. a.overbeek@vumc.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / adverse effects
Birth Weight / drug effects
Cohort Studies
Female
Fetal Growth Retardation / chemically induced,  etiology
Humans
Infertility, Female / chemically induced,  complications*
Neoplasms / complications*,  drug therapy,  therapy
Netherlands
Pregnancy
Pregnancy Outcome
Premature Birth / chemically induced,  etiology
Registries
Reproducibility of Results
Self Report
Siblings
Survivors*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents
Investigator
Investigator/Affiliation:
C C M Beerendonk / ; M H van den Berg / ; J P Bökkerink / ; C van den Bos / ; D Bresters / ; W van Dorp / ; E van Dulmen-den Broeder / ; M P van Engelen / ; M M van den Heuvel-Eibrink / ; G A Huizinga / ; M W M Jaspers / ; G J L Kaspers / ; L C Kremer / ; C B Lambalk / ; J S Laven / ; F E van Leeuwen / ; J J Loonen / ; M Louwerens / ; A Overbeek / ; H J van der Pal / ; C M Ronckers / ; A H M Simons / ; W J E Tissing / ; N Tonch / ; E C M Verkerk / ; A B Versluys /

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