| Validity and reliability of perinatal biomarkers of adiposity after storage as dried blood spots on paper. | |
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MedLine Citation:
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PMID: 21735507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate use of chip-based immunoaffinity capillary electrophoresis on dried blood spot samples (DBSS) to measure obesity-related hormones. METHODS: Chip-based immunoaffinity capillary electrophoresis was used to measure adiponectin, leptin and insulin in capillary serum and DBSS in pregnant women and infant heelstick at birth and six weeks. Concordance of measurements was determined with Pearson's correlation and Bland-Altman plots. RESULTS: We report high concordance between results obtained from serum and DBSS. CONCLUSIONS: Ease of sample collection and storage makes DBSS an optimal method for use in studies involving neonates and young children, as well as studies conducted in areas where freezer storage is not available. |
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Authors:
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Nicole L Mihalopoulos; Terry M Phillips; Hillarie Slater; J Anne Thomson; Michael W Varner; M Nazeem Nanjee; Laurie J Moyer-Mileur |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2011-07-06 |
Journal Detail:
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Title: American journal of human biology : the official journal of the Human Biology Council Volume: 23 ISSN: 1520-6300 ISO Abbreviation: Am. J. Hum. Biol. Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-08-08 Completed Date: 2011-12-13 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8915029 Medline TA: Am J Hum Biol Country: United States |
Other Details:
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Languages: eng Pagination: 717-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, University of Utah, Salt Lake City, Utah 84158, USA. Nicole.mihalopoulos@hsc.utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adiposity Biological Markers / blood Capillaries / chemistry Dried Blood Spot Testing / instrumentation, methods* Electrophoresis, Microchip / instrumentation, methods* Female Humans Infant Infant, Newborn Insulin / blood* Leptin / blood* Obesity / diagnosis Pregnancy Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL092069-02/HL/NHLBI NIH HHS; K23 HL092069-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers; 0/Insulin; 0/Leptin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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