| Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study. | |
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MedLine Citation:
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PMID: 19386578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These patients were considered at risk for psychosis by virtue of meeting research criteria derived from retrospective accounts of the psychosis prodrome. This study evaluated the diagnostic validity of the prospective "prodromal risk syndrome" construct. Patients assessed by the Structured Interview for Prodromal Syndromes as meeting criteria of prodromal syndromes (n = 377) from the North American Prodrome Longitudinal Study were compared with normal comparison (NC, n = 196), help-seeking comparison (HSC, n = 198), familial high-risk (FHR, n = 40), and schizotypal personality disorder (SPD, n = 49) groups. Comparisons were made on variables from cross-sectional demographic, symptom, functional, comorbid diagnostic, and family history domains of assessment as well as on follow-up outcome. Prodromal risk syndrome patients as a group were robustly distinguished from NC subjects across all domains and distinguished from HSC subjects and from FHR subjects on most measures in many of these domains. Adolescent and young adult SPD patients, while distinct from prodromal patients on definitional grounds, were similar to prodromals on multiple measures, consistent with SPD in young patients possibly being an independent risk syndrome for psychosis. The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). |
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Authors:
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Scott W Woods; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Robert Heinssen; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Thomas H McGlashan |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-04-21 |
Journal Detail:
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Title: Schizophrenia bulletin Volume: 35 ISSN: 1745-1701 ISO Abbreviation: Schizophr Bull Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-19 Completed Date: 2009-11-16 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0236760 Medline TA: Schizophr Bull Country: United States |
Other Details:
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Languages: eng Pagination: 894-908 Citation Subset: IM |
Affiliation:
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PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA. scott.woods@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Comorbidity Disability Evaluation Disease Progression Early Diagnosis Female Humans Longitudinal Studies Male Patient Acceptance of Health Care / psychology Psychiatric Status Rating Scales / statistics & numerical data* Psychometrics / statistics & numerical data Psychotic Disorders / diagnosis*, genetics, psychology Reproducibility of Results Risk Assessment Schizophrenia / diagnosis* Schizophrenic Psychology* Schizotypal Personality Disorder / diagnosis*, genetics, psychology Social Adjustment United States Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K05MH01654/MH/NIMH NIH HHS; K24 MH076191-05/MH/NIMH NIH HHS; K24 MH76191/MH/NIMH NIH HHS; P50 MH064065/MH/NIMH NIH HHS; P50 MH080272/MH/NIMH NIH HHS; R01 MH060720-10/MH/NIMH NIH HHS; R01 MH061523/MH/NIMH NIH HHS; R01 MH065079/MH/NIMH NIH HHS; R01 MH065562/MH/NIMH NIH HHS; R01 MH60720/MH/NIMH NIH HHS; R01MH062066/MH/NIMH NIH HHS; R21MH075027/MH/NIMH NIH HHS; U01 MH066069/MH/NIMH NIH HHS; U01 MH066134/MH/NIMH NIH HHS; U01 MH066160/MH/NIMH NIH HHS; U01 MH081944-05/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
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Schizophr Bull. 2009 Sep;35(5):841-3
[PMID:
19633215
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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