| Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. | |
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MedLine Citation:
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PMID: 16449948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Among the non-classic cardiovascular disease risk factors in end-stage renal disease patients on chronic hemodialysis (HD), plasma fibrinogen, D-dimer, and von Willebrand factor (vWf) levels are potential markers of cardiovascular morbidity. We designed this case-control study to investigate their validity and any differences between them. MATERIAL/METHODS: Twenty-five HD patients (18 males, mean age: 63, range: 52-69 years) comprised the group with prevalent cardiovascular disease (CVD) and 50 HD patients (35 males, mean age: 62, range: 40-77 years) with non-evident cardiovascular disease history constituted the second study group. Twenty-five healthy non-smoking volunteers served as controls for comparison with the study groups. RESULTS: Patients with CVD had significantly higher concentrations of plasma fibrinogen, D-dimer, and vWf than patients without incident CVD. All three parameters correlated positively with cardiovascular morbidity, i.e. fibrinogen (r=0.378, P<0.001), logDD (r=0.70, P<0.001), vWf (r=0.214, P<0.001), and logCRP (r=0.704, P<0.001). Among them, D-dimer exhibited the characteristics most coherent with CVD. The age- and sex-adjusted odds ratio (OR) of D-dimer for the presence of CVD was 2.0, which did not change appreciably when adjustments for several pathophysiological clusters of variables were made, except for a marginal reduction in OR following adjustment for markers of inflammation. CONCLUSIONS: Among the coagulation molecules studied, plasma D-dimer levels exhibited the characteristics most coherent with associated CVD and were found to be strongly and independently associated with the prevalence of CVD in HD patients. |
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Authors:
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Dimitrios Kirmizis; Apostolos Tsiandoulas; Maria Pangalou; Evangelia Koutoupa; Paraskevi Rozi; Maria Protopappa; Konstantinos Barboutis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-26 |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 12 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-20 Completed Date: 2006-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR55-62 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Serres General Hospital, Serres, Greece. kirmizis@med.auth.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Cardiovascular Diseases / blood*, etiology Case-Control Studies Female Fibrin Fibrinogen Degradation Products / metabolism* Fibrinogen / metabolism* Humans Kidney Failure, Chronic / blood, complications, therapy Male Middle Aged Odds Ratio Renal Dialysis* Reproducibility of Results von Willebrand Factor / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 0/von Willebrand Factor; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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