| Validity of elevated interstitial levels of taurine as a predictor of myocardial ischemic injury. | |
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MedLine Citation:
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PMID: 15309579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The microdialysis (MD) technique allows for continuous in vivo monitoring of dynamic changes in the interstitial levels of energy-related metabolites. The release of taurine from the myocyte has been suggested as a marker of ischemic injury. The relationship between (interstitial) taurine release and the degree of myocardial ischemic injury was evaluated following a 40 min long ischemia in a porcine heart-infarct-model. Different protocols of ischemia and reperfusion were used in order to achieve a graded level of myocardial injury. Both interstitial peak levels and the area under curve of taurine obtained during ischemia and reperfusion correlated with the degree of ischemic injury (assessed by developed infarct size estimation). The release of taurine in the myocardium measured by the MD-technique correlated with the degree of ischemic injury during ongoing ischemic insult. Hence, taurine determination in the MD-setting represents a powerful tool to follow the development of myocardial ischemic injury over time. |
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Authors:
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M Kavianipour; G Wikström; G Ronquist; A Waldenström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-10-30 |
Journal Detail:
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Title: Amino acids Volume: 27 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-13 Completed Date: 2005-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Norrland University Hospital, Umeå, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Ischemia Myocardial Infarction Myocardial Ischemia / metabolism*, pathology* Myocardial Reperfusion* Myocardium / metabolism* Reperfusion Injury Swine Taurine / biosynthesis*, chemistry, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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107-35-7/Taurine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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