Document Detail

Validity of the T-ACE in pregnancy in predicting child outcome and risk drinking.
MedLine Citation:
PMID:  20053522     Owner:  NLM     Status:  MEDLINE    
Preventing fetal alcohol spectrum disorders (FASDs) requires detection of in-pregnancy maternal risk drinking. The widely used T-ACE screen has been applied in various ways, although the impact of those different uses on effectiveness is uncertain. We examined relations among different T-ACE scoring criteria, maternal drinking, and child outcome. Self-reported across-pregnancy maternal drinking was assessed in 75 African-American women. The different T-ACE criteria used varied the level of drinking that defined tolerance (two or three drinks) and the total T-ACE score cut-points (two or three). Receiver operator curves and regression analysis assessed the significance of relations. Increasing the total T-ACE score cut-point to 3 almost doubled specificity in detecting risk drinking whereas maintaining adequate sensitivity, equivalent to that in the original report, and identified substantially more neurobehavioral deficits in children. Redefining tolerance at three drinks did not improve T-ACE effectiveness in predicting outcomes. This study is among the first to show the ability of an in-pregnancy T-ACE assessment to predict child neurodevelopmental outcome. In addition, increasing the total T-ACE score criterion (from 2 to 3) improved identification of non-drinking mothers and unaffected children with little loss in detection of drinkers and affected children. Efficient in-pregnancy screens for risk drinking afford greater opportunities for intervention that could prevent/limit FASDs.
Lisa M Chiodo; Robert J Sokol; Virginia Delaney-Black; James Janisse; John H Hannigan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-01-06
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  44     ISSN:  1873-6823     ISO Abbreviation:  Alcohol     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-11     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  595-603     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Americans
Alcohol Drinking / adverse effects*,  epidemiology*
Central Nervous System Diseases / diagnosis,  epidemiology,  etiology
Child, Preschool
Drug Tolerance
Fetal Alcohol Spectrum Disorders / diagnosis,  prevention & control*
Mass Screening / methods*
Mental Disorders / diagnosis,  epidemiology,  etiology
Pregnancy Outcome*
Prenatal Exposure Delayed Effects
Prospective Studies
ROC Curve
Regression Analysis
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diagnosis of fetal alcohol spectrum disorders: a validity study of the fetal alcohol syndrome checkl...
Next Document:  RNAi targeting ryanodine receptor 2 protects rat cardiomyocytes from injury caused by simulated isch...