Document Detail

Validity of the EQ-5D in assessing and valuing health status in patients with schizophrenic, schizotypal or delusional disorders.
MedLine Citation:
PMID:  17142014     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The EQ-5D is a generic questionnaire generating a health profile and a single index score for health-related quality of life. This study aimed to analyse the discriminative ability and validity of the EQ-5D in patients with schizophrenic, schizotypal or delusional disorders. SUBJECTS AND METHODS: One hundred sixty-six patients with schizophrenic, schizotypal or delusional disorders (ICD-10 F2) completed the EQ-5D. Measures of quality of life (WHOQOL-BREF), utility (TTO), subjective (SCL-90R) and objective (PANSS, CGI-S) psychopathology, and functioning (GAF, GARF, SOFAS, HoNOS) provided comparison. Discriminative ability was analysed by assessing frequency distributions of EQ-5D scores. Validity of the EQ-5D self-classifier was analysed by assessing differences in related other scores grouped by response levels of EQ-5D items. Validity of the visual analogue scale (EQ VAS) and the EQ-5D index (UK social tariff) was analysed by assessing their correlation with all other scores. RESULTS: Seventy-nine percent of respondents reported problems in at least one of the EQ-5D dimensions (anxiety/depression 57%, usual activities 45%, pain/discomfort 44%, self-care 29%, mobility 22%). The mean EQ VAS score/EQ-5D index was 65.7/0.71. The four most frequently reported EQ-5D health states covered 45% of all respondents. For almost all EQ-5D dimensions, different response levels were associated with significantly different scores of measures used for comparison. Correlation of EQ VAS score and EQ-5D index were largest with scores of subjective measures (SCL-90R: -0.50 and -0.73; WHOQOL mental subscore 0.62 and 0.58; always P<0.001). DISCUSSION AND CONCLUSION: The EQ-5D showed a moderate ceiling effect and seems to be reasonably valid in this patient group.
Hans-Helmut König; Christiane Roick; Matthias C Angermeyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-04
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  22     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  177-87     Citation Subset:  IM    
Health Economics Research Unit, Department of Psychiatry, University of Leipzig, 04317 Leipzig, Germany.
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MeSH Terms
Aged, 80 and over
Anxiety Disorders / diagnosis,  epidemiology,  psychology
Delusions / diagnosis*,  psychology
Depressive Disorder / diagnosis,  epidemiology,  psychology
Disability Evaluation
Health Status Indicators*
Middle Aged
Psychiatric Status Rating Scales / statistics & numerical data
Psychometrics / statistics & numerical data
Quality of Life / psychology*
Reproducibility of Results
Schizophrenia / diagnosis*,  epidemiology
Schizophrenic Psychology*
Schizotypal Personality Disorder / diagnosis*,  epidemiology,  psychology

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