Document Detail

Validation of the use of foreign gas rebreathing method for non-invasive determination of cardiac output in heart disease patients.
MedLine Citation:
PMID:  16358372     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. METHODS: Cardiac outputs measured by Innocor (CO(RB)) were compared with CO obtained by echocardiography (CO(EC)), Swan-Ganz thermodilution (CO(TD)), and left ventricle radiography (CO(LVR)) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS. RESULTS: There was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by thermodilution and between CO(EC) and CO(LVR) values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66+/-0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding CO(EC) and CO(LVR) values. CONCLUSION: Innocor CO(RB) is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.
Liang Dong; Jian-an Wang; Chen-yang Jiang
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Validation Studies    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  6     ISSN:  1673-1581     ISO Abbreviation:  -     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-16     Completed Date:  2006-01-19     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  1157-62     Citation Subset:  IM    
Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
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MeSH Terms
Breath Tests / methods*
Carbon Dioxide / diagnostic use*
Cardiac Output*
Heart Diseases / diagnosis*,  physiopathology*
Heart Function Tests / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
124-38-9/Carbon Dioxide

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