Document Detail

Validation studies using an alloyed gold standard.
MedLine Citation:
PMID:  8322765     Owner:  NLM     Status:  MEDLINE    
A key assumption made when using a validation study to correct an estimate of relative risk for bias due to misclassification or measurement error is that the available measure, known to have error but nonetheless used routinely in the main study, is compared to a gold standard measured without error. In most epidemiologic applications, the putative gold standard is in fact measured with error. The effect of the violation of the assumption on the corrected estimate depends on the magnitudes of the errors in the two measures and on their correlation. In particular, when the errors are negatively correlated, independent, or weakly positively correlated, the corrected estimate will tend to overcorrect beyond the true value.
S Wacholder; B Armstrong; P Hartge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of epidemiology     Volume:  137     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1251-8     Citation Subset:  IM    
National Cancer Institute, Epidemiology and Biostatistics Program, Bethesda, MD.
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MeSH Terms
Bias (Epidemiology)
Effect Modifiers (Epidemiology)
Epidemiologic Methods*
Reproducibility of Results
Comment In:
Am J Epidemiol. 1994 Apr 15;139(8):853-4   [PMID:  8178797 ]
Am J Epidemiol. 1995 Feb 1;141(3):276-7   [PMID:  7840104 ]
Am J Epidemiol. 1996 Jun 1;143(11):1175-6   [PMID:  8633609 ]

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