Document Detail

Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults.
MedLine Citation:
PMID:  12396157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To validate assessment of soy intake using food frequency questionnaires (FFQs) compared with plasma isoflavone (genistein and daidzein) concentrations. DESIGN: Cross-sectional analysis of soy isoflavone intake and plasma analysis of isoflavones. SUBJECTS: 77 men and women, age range 20 to 40 years, recruited from the Seattle metropolitan area. MAIN OUTCOME MEASURES: Isoflavone intake was determined from responses to a 40-item soy FFQ and from tofu and soymilk intake assessed as part of a comprehensive FFQ used for the Women's Health Initiative (WHI FFQ). Isoflavone concentrations in fasting blood samples were determined by liquid chromatography-mass spectrometry. STATISTICAL ANALYSES: Correlation coefficients were calculated for: a) isoflavone intake assessed by the soy FFQ and the WHI FFQ, b) intake assessed by the soy FFQ and plasma isoflavone concentrations, and c) intake assessed by the WHI FFQ and plasma isoflavone concentrations. RESULTS: Isoflavone intake was highly correlated between the soy FFQ and the WHI FFQ (r = 0.84). Genistein and daidzein intakes determined by the soy FFQ were significantly correlated with plasma concentrations (r = 0.53 and 0.45, respectively). Isoflavone intake assessed from the WHI FFQ was also correlated with plasma concentration (r = 0.46 and 0.45). Soymilk and tofu were the two major contributors to isoflavone intake (38.6%). CONCLUSIONS: A soy-specific, 40-item FFQ assessed isoflavone intake with good validity. Isoflavone intake assessed by the WHI FFQ (tofu and soymilk) had lower correlations with plasma concentrations compared with the soy FFQ. Nonetheless, assessment of the two foods is a reasonably good marker for soy food consumption in this sample.
Cara L Frankenfeld; Ruth E Patterson; Thomas F Kalhorn; Heather E Skor; William N Howald; Johanna W Lampe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Validation Studies    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  102     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2002-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1407-13     Citation Subset:  AIM; IM    
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
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MeSH Terms
Cross-Sectional Studies
Diet Surveys
Gas Chromatography-Mass Spectrometry
Genistein / administration & dosage,  blood*
Isoflavones / administration & dosage,  blood*
Questionnaires / standards*
Reproducibility of Results
Soybeans* / chemistry
Grant Support
M01-N-00037//PHS HHS; R01 CA70913/CA/NCI NIH HHS; R03 CA80648/CA/NCI NIH HHS
Reg. No./Substance:
0/Isoflavones; 446-72-0/Genistein; 486-66-8/daidzein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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