| Validation of self-report of rheumatoid arthritis and systemic lupus erythematosus: The Women's Health Initiative. | |
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MedLine Citation:
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PMID: 18398940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The Women's Health Initiative (WHI), initiated in 1993, enrolled 161,808 postmenopausal women aged 50-79 years and followed them with annual questionnaires for 8 years in order to study major causes of morbidity and mortality. Our objective was to determine the most effective and efficient means to validate self-reported rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in the WHI. METHODS: Data from 2 of 40 WHI clinical centers were used. Of these 7443 women, 643 self-reported RA and 106 self-reported SLE. Research coordinators contacted these women using mailers and telephone calls to obtain medical record releases and a Connective Tissue Screening Questionnaire (CSQ). Medical records were obtained on 286 self-reported RA and 34 self-reported SLE and reviewed by 3 rheumatologists blind to the self-reported diagnoses. Sensitivity, specificity, and the kappa statistic were computed to evaluate the level of agreement between self-report and chart review. RESULTS: Self-reported RA was accurate only 14.7% (42/286 cases) of the time. Coupling the self-report to medication data improved the positive predictive value (PPV; 62.2%) and kappa (0.53), suggesting a moderate agreement to chart review. Self-reported SLE was accurate only 11.8% (4/34 cases) of the time. Coupling the self-report to medication data improved the PPV (40.0%) and kappa (0.44), suggesting a moderate agreement to chart review. The CSQ was inferior to using medication data but was substantially better than self-report alone. CONCLUSION: The performance of disease self-report coupled with medication history in validating RA and SLE was very good and should obviate the need for time-consuming medical record reviews. |
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Authors:
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Brian T Walitt; Florina Constantinescu; James D Katz; Arthur Weinstein; Hong Wang; Rohini K Hernandez; Judith Hsia; Barbara V Howard |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2008-04-01 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 35 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-08 Completed Date: 2008-08-21 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 811-8 Citation Subset: IM |
Affiliation:
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Georgetown University, Washington, DC, USA. Brian.t.walitt@medstar.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arthritis, Rheumatoid / diagnosis* Female Health Surveys* Humans Lupus Erythematosus, Systemic / diagnosis* Middle Aged Self Disclosure* Sensitivity and Specificity Single-Blind Method Women's Health* |
| Grant Support | |
ID/Acronym/Agency:
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N01 WH022110-024/WH/WHI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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