Document Detail


Validation of self-report and hospital pill count using unannounced home pill count as methods for determination of adherence to antiretroviral therapy.
MedLine Citation:
PMID:  18846785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adherence to anti-retroviral therapy (ART) is very crucial for successful treatment outcomes. This study aimed to validate patient-self report (PSR) and hospital based pill count (HoPC) as adherence determination methods by using unannounced home visit pill count (HPC). The study was carried out at Muhimbili National Hospital in Dar es Salaam, Tanzania and 215 patients purposively selected were recruited. On refill day, the remaining pills were counted. They were also asked to report on the number of doses they missed during the past 28 days. They were later visited in their homes without appointment where the remaining pills were counted. Ninety-eight percent and 93% reported to adhere to ART by PSR method and HoPC, respectively. However, only 58% of the same study patients were found to be adherent by > or = 95% using HPC. In conclusion, PSR and HoPC do not always give reliable adherence data in patients undergoing ART. Therefore, we recommend application of combination methods for adherence measuring in patients starting to include patient self report and hospital based pill count in new patients and complementing them with unannounced home based pill count in experienced patients. Wherever possible, drug plasma concentration measurements should also be established.
Authors:
O M S Minzi; A S Naazneen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Tanzania journal of health research     Volume:  10     ISSN:  1821-6404     ISO Abbreviation:  -     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479163     Medline TA:  Tanzan J Health Res     Country:  Tanzania    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Affiliation:
Muhimbili University of Health and Allied Sciences, School of Pharmacy, P.O. Box 65013, Dares Salaam, Tanzania. ominzi@muchs.ac.tz
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Retroviral Agents / administration & dosage*
Drug Administration Schedule
Female
HIV Infections / drug therapy*
Humans
Male
Middle Aged
Patient Compliance*
Prospective Studies
Self Administration
Tanzania
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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