Document Detail


Validation of the rosette inhibition test for the detection of early pregnancy in women.
MedLine Citation:
PMID:  6177559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors validated use of the rosette inhibition test for the detection of early pregnancy factor (EPF) in human pregnancy, first by optimizing conditions for the assay, using known pregnant and nonpregnant sera, and second, by examining the performance of this assay in three clinical situations: a "blind" study involving coded first-trimester sera showed 80% correlation with pregnancy status; serial assay of EPF activity in sera collected from normal women attempting to conceive, correlated with human chorionic gonadotropin beta-subunit (beta-hCG) levels and pregnancy status; a longitudinal study of serial serum samples through two normal pregnancies showing the continued presence of EPF until the early third trimester in each case. It was concluded that with the rosette inhibition assay, consistent demonstration of a pregnancy-associated substance (EPF) could be obtained.
Authors:
Y C Smart; T K Roberts; I S Fraser; A W Cripps; R L Clancy
Related Documents :
4015199 - Routine quantification of rheumatoid factor by rate nephelometry.
16726709 - Ovarian steroid secretion changes after hcg stimulation in early pregnant pigs.
2458379 - Trophoblastic and decidual response to ru486: effects on human chorionic gonadotrophin,...
17939589 - Endometrial stripe thickness and pregnancy outcome in first-trimester pregnancies with ...
6952279 - Hormonal profile during termination of midtrimester pregnancy by extraovular instillati...
11028579 - First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy as...
326049 - A comparison of methods for quantitating fetal heart rate variability.
17765669 - Prediction and perinatal outcomes of fetal growth restriction.
19328479 - Cumulative pregnancy probabilities among couples with subfertility: effects of varying ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  37     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  779-85     Citation Subset:  IM; J    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chaperonin 10
Chorionic Gonadotropin / blood
Chorionic Gonadotropin, beta Subunit, Human
Female
Humans
Immunosuppressive Agents / blood*
Longitudinal Studies
Lymphocytes / immunology
Menstruation
Peptide Fragments / blood
Peptides*
Pregnancy
Pregnancy Proteins*
Pregnancy Tests, Immunologic / methods*
Rosette Formation*
Suppressor Factors, Immunologic*
Chemical
Reg. No./Substance:
0/Chaperonin 10; 0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Immunosuppressive Agents; 0/Peptide Fragments; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adjuvant arthritis: immunopathological and hyperalgesic features.
Next Document:  Transplantation antigens and keratoplasty.