Document Detail

Validation of the rosette inhibition test for the detection of early pregnancy in women.
MedLine Citation:
PMID:  6177559     Owner:  NLM     Status:  MEDLINE    
The authors validated use of the rosette inhibition test for the detection of early pregnancy factor (EPF) in human pregnancy, first by optimizing conditions for the assay, using known pregnant and nonpregnant sera, and second, by examining the performance of this assay in three clinical situations: a "blind" study involving coded first-trimester sera showed 80% correlation with pregnancy status; serial assay of EPF activity in sera collected from normal women attempting to conceive, correlated with human chorionic gonadotropin beta-subunit (beta-hCG) levels and pregnancy status; a longitudinal study of serial serum samples through two normal pregnancies showing the continued presence of EPF until the early third trimester in each case. It was concluded that with the rosette inhibition assay, consistent demonstration of a pregnancy-associated substance (EPF) could be obtained.
Y C Smart; T K Roberts; I S Fraser; A W Cripps; R L Clancy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  37     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  779-85     Citation Subset:  IM; J    
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MeSH Terms
Chaperonin 10
Chorionic Gonadotropin / blood
Chorionic Gonadotropin, beta Subunit, Human
Immunosuppressive Agents / blood*
Longitudinal Studies
Lymphocytes / immunology
Peptide Fragments / blood
Pregnancy Proteins*
Pregnancy Tests, Immunologic / methods*
Rosette Formation*
Suppressor Factors, Immunologic*
Reg. No./Substance:
0/Chaperonin 10; 0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Immunosuppressive Agents; 0/Peptide Fragments; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor

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