| Validation of questionnaire-based long-term dietary exposure to polychlorinated biphenyls using biomarkers. | |
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MedLine Citation:
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PMID: 22976994 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SCOPE: The health consequences of lifelong low-level exposure to polychlorinated biphenyls (PCBs) via food are largely unknown, mainly due to the lack of large population-based prospective studies addressing this issue. We validated long-term food frequency questionnaire (FFQ)-based dietary PCB exposure against concentrations of six PCB congeners in serum. METHODS AND RESULTS: Dietary PCB exposure was estimated in the Swedish Mammography Cohort by constructing a recipe-based database of CB-153, an indicator for total PCBs in food. The Spearman rank correlation (adjusted for within-person variability) was assessed between concurrent (2004-2006), past (1997), and long-term (mean of 1997 and 2004-2006) FFQ-based dietary PCB exposure, respectively, and the following serum PCB congeners, CB-118, CB-138, CB-153, CB-156, CB-170, and CB-180, in women (56-85 years of age, n = 201). The correlation between FFQ-based dietary PCB exposure and serum CB-153 was 0.41 (p < 0.001) for the concurrent (median 1.6 ng/kg body weight) and 0.34 (p < 0.05) for the past (median 2.6 ng/kg body weight) exposure assessment. Long-term validity of FFQ-based PCB estimates and the six serum PCB congeners ranged from 0.30 to 0.58 (p < 0.05). CONCLUSION: FFQ-based PCB exposure estimates show acceptable validity in relation to PCB concentrations in serum, justifying their use in large-scale epidemiological studies. |
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Authors:
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Charlotte Bergkvist; Agneta Akesson; Anders Glynn; Karl Michaëlsson; Panu Rantakokko; Hannu Kiviranta; Alicja Wolk; Marika Berglund |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
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Title: Molecular nutrition & food research Volume: - ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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