Document Detail


Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I.
MedLine Citation:
PMID:  19433710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP).
METHODS: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered.
RESULTS: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated.
CONCLUSION: The WINROP algorithm may be a useful tool for modification of ROP screening.
Authors:
Chatarina Löfqvist; Ingrid Hansen-Pupp; Eva Andersson; Kristina Holm; Lois E H Smith; David Ley; Ann Hellström
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  127     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-05-22     Revised Date:  2014-03-10    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  622-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Biological Markers / blood*
Birth Weight / physiology*
False Positive Reactions
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature / blood*
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / analysis*
Male
Predictive Value of Tests
Prospective Studies
Radioimmunoassay
Reproducibility of Results
Retinopathy of Prematurity / blood*,  etiology
Risk Factors
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 EY017017/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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