| Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. | |
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MedLine Citation:
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PMID: 19433710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). METHODS: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. RESULTS: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated. CONCLUSION: The WINROP algorithm may be a useful tool for modification of ROP screening. |
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Authors:
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Chatarina Löfqvist; Ingrid Hansen-Pupp; Eva Andersson; Kristina Holm; Lois E H Smith; David Ley; Ann Hellström |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Archives of ophthalmology Volume: 127 ISSN: 1538-3601 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 622-7 Citation Subset: AIM; IM |
Affiliation:
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Section of Pediatric Ophthalmology, The Queen Silvia Children's Hospital, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. chatarina.lofqvist@vgregion.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Biological Markers / blood* Birth Weight / physiology* False Positive Reactions Female Gestational Age Humans Infant Infant, Newborn Infant, Premature / blood* Insulin-Like Growth Factor Binding Protein 3 / blood Insulin-Like Growth Factor I / analysis* Male Predictive Value of Tests Prospective Studies Radioimmunoassay Reproducibility of Results Retinopathy of Prematurity / blood*, etiology Risk Factors Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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