Document Detail

Validation of a new method of measuring esophageal acid exposure: comparison with 24-hour pH monitoring.
MedLine Citation:
PMID:  12645785     Owner:  NLM     Status:  MEDLINE    
Recently, we developed a disposable acid exposure sensor whose in vitro response to acid below pH 4 is linearly determined by the duration of exposure and the degree of acidity. The aim of the present study was to compare the SR to simultaneous esophageal pH and duodenogastroesophageal reflux (DGER) monitoring (Bilitec) in patients investigated for presumed gastroesophageal reflux disease (GERD). Twenty-six patients (16 men, mean age 46 +/- 2 years) with symptoms suggestive of GERD underwent 24-hr ambulatory pH monitoring and SR monitoring at 5 cm proximal to the LES. DGER monitoring was performed in 21 patients. Exposure of the esophagus to acid and to DGER were analyzed. These data were compared to SR. A significant correlation was found between the exposure of the distal esophagus to acid and SR (R = 0.85; P < 0.0001). Similarly, the area below a cutoff pH 4 was significantly correlated to SR (r = 0.81; P < 0.0001). SR was not correlated to DGER (r = 0.16; NS). At a cutoff of 50, the sensitivity and specificity of SR to predict esophageal acid exposure > 5% of time were 91% and 93%, respectively conclusion, the response of the acid exposure sensor is strongly correlated with the results of simultaneous esophageal pH monitoring. The sensor seems able to reliably predict pathological esophageal acid exposure. These findings warrant larger studies of the clinical potential of the acid exposure sensor in the diagnosis and quantification of GERD.
J Tack; G Vantrappen; G Huyberechts; D Sifrim; J Janssens; R Van Overstraeten
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  48     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  AIM; IM    
Center for Gastroenterological Research, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
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MeSH Terms
Bile Reflux / diagnosis
Disposable Equipment
Duodenogastric Reflux / diagnosis
Gastroesophageal Reflux / diagnosis*
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Ambulatory / instrumentation*
Pilot Projects
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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