Document Detail


Validation of a new method for automated determination of bone age in Japanese children.
MedLine Citation:
PMID:  20389112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BoneXpert, an automated method for analysis of hand radiographs of children, has recently been developed and validated in European children. It determines Tanner-Whitehouse (TW) and Greulich Pyle (GP) bone ages (BA). The purpose of this work is to validate BoneXpert BA in Japanese children and determine the following two properties of the method: (1) The accuracy of the BA, i.e. the standard deviation from an experienced Japanese TW BA rater. (2) The precision of the BA, i.e. BoneXpert's ability to yield the same BA value on a repeated radiograph. The data consist of two studies: 185 radiographs of 22 normal children followed longitudinally from approximately 7 years to full maturity, and 284 radiographs of 22 patients with growth hormone deficiency treated with growth hormone and gonadotropin-releasing hormone analogue followed from an age of 4-11 years to almost full maturity. All radiographs were rated manually according to the TW-Japan system. BoneXpert processed all images, and the accuracy (SD) of TW-Japan BA was 0.72 years (95% CI 0.68-0.76). The precision error (SD) on a single determination of GP BA was 0.17 years (95% CI 0.15-0.19). It is concluded that BoneXpert performs as well in Japanese children as it does in Caucasian children. This study accomplishes a calibration of BoneXpert to the TW-Japan standard, which performs well for the entire BA range from 4 years up to full maturity.
Authors:
David D Martin; Koshi Sato; Mari Sato; Hans Henrik Thodberg; Toshiaki Tanaka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-04-14
Journal Detail:
Title:  Hormone research in pædiatrics     Volume:  73     ISSN:  1663-2826     ISO Abbreviation:  Horm Res Paediatr     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Tübingen University, Tübingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Determination by Skeleton / methods
Asian Continental Ancestry Group
Child
Child, Preschool
Female
Growth Hormone / deficiency
Hand / radiography*
Humans
Japan
Male
Radiographic Image Interpretation, Computer-Assisted / methods
Reproducibility of Results
Chemical
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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