| Validation of a new method for automated determination of bone age in Japanese children. | |
| | |
MedLine Citation:
|
PMID: 20389112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BoneXpert, an automated method for analysis of hand radiographs of children, has recently been developed and validated in European children. It determines Tanner-Whitehouse (TW) and Greulich Pyle (GP) bone ages (BA). The purpose of this work is to validate BoneXpert BA in Japanese children and determine the following two properties of the method: (1) The accuracy of the BA, i.e. the standard deviation from an experienced Japanese TW BA rater. (2) The precision of the BA, i.e. BoneXpert's ability to yield the same BA value on a repeated radiograph. The data consist of two studies: 185 radiographs of 22 normal children followed longitudinally from approximately 7 years to full maturity, and 284 radiographs of 22 patients with growth hormone deficiency treated with growth hormone and gonadotropin-releasing hormone analogue followed from an age of 4-11 years to almost full maturity. All radiographs were rated manually according to the TW-Japan system. BoneXpert processed all images, and the accuracy (SD) of TW-Japan BA was 0.72 years (95% CI 0.68-0.76). The precision error (SD) on a single determination of GP BA was 0.17 years (95% CI 0.15-0.19). It is concluded that BoneXpert performs as well in Japanese children as it does in Caucasian children. This study accomplishes a calibration of BoneXpert to the TW-Japan standard, which performs well for the entire BA range from 4 years up to full maturity. |
| | |
Authors:
|
David D Martin; Koshi Sato; Mari Sato; Hans Henrik Thodberg; Toshiaki Tanaka |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-04-14 |
Journal Detail:
|
Title: Hormone research in pædiatrics Volume: 73 ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-04-14 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 398-404 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 S. Karger AG, Basel. |
Affiliation:
|
Tübingen University, Tübingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Determination by Skeleton / methods Asian Continental Ancestry Group Child Child, Preschool Female Growth Hormone / deficiency Hand / radiography* Humans Japan Male Radiographic Image Interpretation, Computer-Assisted / methods Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
|
9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship of muscle function to auxology in preterm born children at the age of seven years.
Next Document: Ectopic Cushing's syndrome due to an adrenal ganglioneuroma.