| Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography. | |
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MedLine Citation:
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PMID: 17245532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Combining the functional information of SPECT myocardial perfusion imaging (SPECT-MPI) and the morphological information of coronary CT angiography (CTA) may allow easier evaluation of the spatial relationship between coronary stenoses and perfusion defects. The aim of the present study was the validation of a novel software solution for three-dimensional (3D) image fusion of SPECT-MPI and CTA. METHODS: SPECT-MPI with adenosine stress/rest 99mTc-tetrofosmin was fused with 64-slice CTA in 15 consecutive patients with a single perfusion defect and a single significant coronary artery stenosis (>or=50% diameter stenosis). 3D fused SPECT/CT images were analysed by two independent observers with regard to superposition of the stenosed vessel onto the myocardial perfusion defect. Interobserver variability was assessed by recording the X, Y, Z coordinates for the origin of the stenosed coronary artery and the centre of the perfusion defect and measuring the distance between the two landmarks. RESULTS: SPECT-MPI revealed a fixed defect in seven patients, a reversible defect in five patients and a mixed defect in three patients and CTA documented a significant stenosis in the respective subtending coronary artery. 3D fused SPECT/CT images showed a match of coronary lesion and perfusion defect in each patient and the fusion process took less than 15 min. Interobserver variability was excellent for landmark detection (r = 1.00 and r = 0.99, p < 0.0001) and very good for the 3D distance between the two landmarks (r = 0.94, p < 0.001). CONCLUSION: 3D SPECT/CT image fusion is feasible, reproducible and allows correct superposition of SPECT segments onto cardiac CT anatomy. |
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Authors:
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Oliver Gaemperli; Tiziano Schepis; Victor Kalff; Mehdi Namdar; Ines Valenta; Laurent Stefani; Lotus Desbiolles; Sebastian Leschka; Lars Husmann; Hatem Alkadhi; Philipp A Kaufmann |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2007-01-24 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 34 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-13 Completed Date: 2007-10-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1097-106 Citation Subset: IM |
Affiliation:
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Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Angiography / methods* Coronary Artery Disease / complications, diagnosis* Female Humans Imaging, Three-Dimensional / methods* Male Middle Aged Reproducibility of Results Sensitivity and Specificity Software* Software Validation Subtraction Technique* Systems Integration Tomography, Emission-Computed, Single-Photon / methods* Tomography, X-Ray Computed / methods* Ventricular Dysfunction, Left / diagnosis, etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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