Document Detail


Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases.
MedLine Citation:
PMID:  18596548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is limited information on the validity of the pathologic criteria of the Third Consortium on Dementia with Lewy bodies (CDLB), and none are based on prospectively diagnosed cases. In this study, the core clinical features of dementia with Lewy bodies (DLB) and the suggestive clinical feature of rapid eye movement sleep behavior disorder were assessed using a battery of standardized clinical instruments in 76 patients with the clinical diagnosis of either DLB or Alzheimer disease. At autopsy, 29 patients had high-likelihood, 17 had intermediate-likelihood, and 6 had low-likelihood DLB pathology. The frequency of core clinical features and the accuracy of the clinical diagnosis of probable DLB were significantly greater in high-likelihood than in low-likelihood cases. This is consistent with the concept that the DLB clinical syndrome is directly related to Lewy body pathology and inversely related to Alzheimer pathology. Thus, the Third Consortium on DLB neuropathologic criteria scheme performed reasonably well and are useful for estimating the likelihood of the premortem DLB syndrome based on postmortem findings. In view of differences in the frequency of clinically probable DLB in cases with Braak neurofibrillary tangle stages V (90%) and VI (20%) and diffuse cortical Lewy bodies, a possible modification of the scheme is to consider cases with neurofibrillary tangle stage VI to be low-likelihood DLB.
Authors:
Hiroshige Fujishiro; Tanis J Ferman; Bradley F Boeve; Glenn E Smith; Neill R Graff-Radford; Ryan J Uitti; Zbigniew K Wszolek; David S Knopman; Ronald C Petersen; Joseph E Parisi; Dennis W Dickson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  67     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-19     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-56     Citation Subset:  IM    
Affiliation:
Department of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Brain / metabolism,  pathology*
Female
Humans
Lewy Bodies / metabolism,  pathology
Lewy Body Disease / complications,  pathology*
Male
Middle Aged
Neurofibrillary Tangles / pathology*
Pathology / methods,  standards*
Plaque, Amyloid / metabolism,  pathology
Predictive Value of Tests
Prospective Studies
REM Sleep Behavior Disorder / etiology
Reproducibility of Results
alpha-Synuclein / metabolism
Grant Support
ID/Acronym/Agency:
P50 AG 16574/AG/NIA NIH HHS; P50 AG016574-109002/AG/NIA NIH HHS; P50 NS 40256/NS/NINDS NIH HHS; P50 NS040256-06/NS/NINDS NIH HHS; P50 NS040256-109004/NS/NINDS NIH HHS; R01 AG 15866/AG/NIA NIH HHS; R01 AG015866-10/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/alpha-Synuclein
Comments/Corrections

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