Document Detail

Validation and interpretation of the Dutch version of the Multiple Sclerosis Neuropsychological Screening Questionnaire.
MedLine Citation:
PMID:  22805106     Owner:  NLM     Status:  Publisher    
BACKGROUND: The Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) was developed for screening of MS patients at risk for cognitive impairment with a patient self-report (MSNQ-P) and an informant version (MSNQ-I). The objective of this study was to validate the Dutch versions and determine their interpretability. METHODS: The MSNQ was completed by 121 MS patients and their partners (informants). We investigated the factor structure, internal consistency and construct validity. Interrater reliability between MNSQ-P and MSNQ-I was investigated with the intraclass correlation coefficient (ICC) and Cohen's kappa. For interpretability of both MSNQ versions we calculated sensitivity, specificity and cut-off scores. Receiver operating characteristic (ROC) curves with related area under the curve (AUC) were used to evaluate the added value of combining both versions. RESULTS: We found a unidimensional factor structure. Cronbach's alphas were 0.93 and 0.94 for MSNQ-P and MSNQ-I, respectively. The ICC was 0.59 and kappas were ≤0.50. No cut-off score could be defined for the MSNQ-P because of low sensitivity. For the MSNQ-I, sensitivity was 0.75 and specificity 0.71 (AUC 0.80). The cut-off score was 21. ROC curve analyses showed no added value of the MSNQ-P when used in combination with the MSNQ-I. CONCLUSIONS: The MSNQ-I is preferred over the MSNQ-P to screen MS patients for cognitive impairment.
Judith M Sonder; Lidwine B Mokkink; Femke A H van der Linden; Chris H Polman; Bernard M J Uitdehaag
Related Documents :
22336696 - Uses of the postural stability test for differential diagnosis of hereditary ataxias.
3917596 - The role of imaging in infertility management.
21188236 - Fc γ riia genotypes and its association with anti-c1q autoantibodies in lupus nephriti...
7221766 - Leiomyoma of the ovary. a report of 3 cases.
9478086 - Multiorgan damage in acute oral carbamates poisonings.
1000456 - Perforation of the gallbladder: analysis of 19 cases.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-15
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, The Netherlands; Department of Neurology, VU University Medical Center Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Open access versus subscription journals: a comparison of scientific impact.
Next Document:  No Improvement in Endurance Performance Following a Single Dose of Beetroot Juice.