Document Detail


Validation of image registration and fusion of MV CBCT and planning CT for radiotherapy treatment planning.
MedLine Citation:
PMID:  21830106     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In areas like adaptive therapy, multi-phase radiotherapy, and single fraction palliative treatment or in the treatment of patients with metal implants where megavoltage(MV) CT could be considered as a treatment planning modality, the reduced contrast in the MV CT images could lead to limited accuracy in localization of the structures. This would affect the precision of the treatment. In this study, as an extension our previous work on bespoke MV cone beam CT (MV CBCT), we propose to register the MV CBCT with kilovoltage (kV) CT for treatment planning. The MV CBCT images registered with kV CT would be effective for treatment planning as it would account for the inadequate soft tissue information in the MV CBCT and would allow comparison of changes in patient dimensions and assist in localization of the structures. The intensity based registration algorithm of the BrainSCAN therapy planning software was used for image registration of the MV CBCT and kV CT images. The accuracy of the registration was validated using qualitative and quantitative measures. The effect of image quality on the level of agreement between the contouring done on both the MV CBCT and kV CT was assessed by comparing the volumes of six structures delineated. To assess the level of agreement between the plans after the registration, two independent plans were generated on the MV CBCT and the planning CT using the posterior fossa of the skull as the target. The dose volume histograms and conformity indices of the plans were compared. The results of this study show that treatment planning with MV CBCT images would be effective, using additional anatomical structure information derived from registering the MV CBCT image with a standard kVCT.
Authors:
T Hannah Mary Thomas; D Devakumar; S Balukrishna; Henry Finlay Godson; B Paul Ravindran
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-10
Journal Detail:
Title:  Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine     Volume:  -     ISSN:  0158-9938     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208130     Medline TA:  Australas Phys Eng Sci Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Bioengineering, Christian Medical College, Vellore, India, hannahrheathomas@gmail.com.
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