| Validation of four clinical indicators of preventable drug-related morbidity. | |
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MedLine Citation:
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PMID: 14742787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinical indicators are tools that assess quality issues related to the use of medicines. At this time, validated clinical indicators for preventable drug-related morbidity (PDRM) are lacking. OBJECTIVE: To assess the validity and reliability of using population administrative claims data to identify the extent of PDRM in older adults in Canada. METHODS: Four indicators of PDRM related to cerebrovascular and cardiovascular care were chosen for validation. A random sample of cases that represented the indicators and fit the criteria (hits) for PDRM from the retrospective operationalization of the study database and those that did not fit the criteria (near hits) were selected for chart review. One-page abstracts of the cases were prepared for review by a panel of 5 clinical pharmacists. Validity was assessed by calculating sensitivity, specificity, and positive and negative predictive value. Reliability was assessed using reviewers' agreement scores (kappa statistics). RESULTS: Overall, 119 case abstracts were reviewed by each panelist. The sensitivity ranged from 33% to 100% and the specificity from 51% to 71%. Predictive values ranged from 5.3% to 43% (positive) and 90% to 100% (negative). The overall kappa statistic was fair (0.21). CONCLUSIONS: The validity of the 4 assessed PDRM indicators varied. The reliability was fair; however, these indicators may be useful to screen older adults for PDRM. |
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Authors:
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Priti S Flanagan; Neil J MacKinnon; Susan K Bowles; Susan A Kirkland |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 38 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-26 Completed Date: 2004-03-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: IM |
Affiliation:
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Health Outcomes Management, College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Canada Cerebrovascular Disorders / drug therapy, epidemiology, prevention & control Female Heart Failure / drug therapy, epidemiology, prevention & control Humans Male Medication Errors / mortality, prevention & control Myocardial Infarction / drug therapy, epidemiology, prevention & control Patient Selection Predictive Value of Tests Quality Indicators, Health Care* Risk Factors Sensitivity and Specificity Thromboembolism / drug therapy, epidemiology, prevention & control Treatment Failure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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