Document Detail


Validation and fine mapping of a QTL for ovulation rate on swine chromosome 3.
MedLine Citation:
PMID:  22404359     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ovulation rate (OR) is an important component of litter size, but mutation(s) in gene(s) underlying OR QTL have yet to be identified in pigs. Markers within an OR QTL on SSC3 were genotyped in three white composite lines selected for ten generations for increased OR or uterine capacity (UC), with one line being an unselected control. Numbers of corpora lutea (CL) and UC (number of fully formed fetuses) were collected at approximately 105 days of gestation, as well as ovary weight (OW), uterine length (UL) and uterine weight (UW) measurements at 160 d of age in generation 12 and 13 females from all three lines. Six microsatellites and ten single nucleotide polymorphisms (SNPs; 0-42 cM) were genotyped in pigs from all lines of generations 11 through 13. The allele frequencies of 24269.1, SW2429, 7907.2 and 7637.2 were different (P < 0.01) in the OR line compared to the control line. A significant (P < 0.05) association of CL with 24269.1 (additive effect 0.65 ± 0.32) was detected, and additive genotypic effects approached significance for markers at 28 through 35 cM (16963.2, 27514.1 and SWR1637). Haplotyping of 7637.2 and 16963.2 (31 through 32 cM) identified a significant additive association of haplotype 1 with CL (-0.62 ± 0.30). These markers were also associated with OW (24296.1 and SWR1637), UL (16963.2, 27514.1 and haplotypes of 7637.2/16963.2) and UW (haplotypes of 7637.2/16963.2). This study verifies an OR QTL on SSC3. However, based on the data, it was concluded that there may be two genes, at 13 through 18 cM and 28 through 35 cM, controlling OR on SSC3p.
Authors:
M R Mousel; K A Leymaster; R K Christenson; D J Nonneman; G A Rohrer
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Publication Detail:
Type:  Journal Article     Date:  2011-08-15
Journal Detail:
Title:  Animal genetics     Volume:  43     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
Affiliation:
USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE 68933-0166, USA.
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