| Validation of equilibration and chromium reduction methods for deuterium measurements of fluid volumes. | |
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MedLine Citation:
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PMID: 11457788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Determinations of fluid volumes are of importance for correct treatment of patients subjected to shock and trauma. Gas isotope ratio mass spectrometry (GIRMS) is an advanced method for analysis of stable isotopes. These can be used as tracers for measurement of various fluid volumes. In the current in vitro study, deuterium was used to determine different volumes of water simulating a range of body fluid volumes from neonates to adults. A high-precision scale gave control weights (i.e., volumes), and two methods, equilibration (EQ) and chromium reduction (CR), were compared by use of a GIRMS. The coefficient of variation was <1% when using both EQ (0.45%) and CR (0.79%). The variability was greater at small volumes, and, when regression equations for the relation between measured and calculated volumes were used as formulas, the deviation was 0.4% using EQ and 2.8% using CR at the volume of 1,000 ml. At larger volumes, the deviation when using CR approached 1%. These variations are better than previously published data using other methods. It was concluded that GIRMS is a suitable technique for fluid volume determinations in neonates as well as in adult patients, using deuterium as a tracer. EQ and CR methods were both regarded to give acceptable variabilities in this in vitro study. GIRMS may in the future increasingly be used clinically for accurate measurements of body fluid volumes. |
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Authors:
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T Hedestig; A Ebberyd; S G Lindahl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 91 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-17 Completed Date: 2001-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 733-6 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, Karolinska Hospital and Institute, S-171 76 Stockholm, Sweden. thore.hedestig@kirurgi.ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Fluids
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chemistry,
physiology* Body Water / chemistry, physiology* Chromium* Deuterium Humans Mass Spectrometry / methods Oxidation-Reduction Regression Analysis Reproducibility of Results Sensitivity and Specificity Shock / physiopathology Wounds and Injuries / physiopathology |
| Chemical | |
Reg. No./Substance:
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7440-47-3/Chromium; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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