| Validation of dynamic contrast-enhanced ultrasound in rodent kidneys as an absolute quantitative method for measuring blood perfusion. | |
| | |
MedLine Citation:
|
PMID: 21601135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Contrast-enhanced ultrasound (CEUS) has demonstrated utility in the monitoring of blood flow in tissues, organs and tumors. However, current CEUS methods typically provide only relative image-derived measurements, rather than quantitative values of blood flow in milliliters/minute per gram of tissue. In this study, CEUS derived parameters of blood flow are compared with absolute measurements of blood flow in rodent kidneys. Additionally, the effects of contrast agent infusion rate and transducer orientation on image-derived perfusion measurements are assessed. Both wash-in curve and time-to-refill algorithms are examined. Data illustrate that for all conditions, image-derived flow measurements were well-correlated with transit-time flow probe measurements (R > 0.9). However, we report differences in the sensitivity to flow across different transducer orientations as well as the contrast analysis algorithm utilized. Results also indicate that there exists a range of contrast agent flow rates for which image-derived estimates are consistent. |
| | |
Authors:
|
Paul Kogan; Kennita A Johnson; Steven Feingold; Nicholas Garrett; Ismayil Guracar; William J Arendshorst; Paul A Dayton |
Related Documents
:
|
22254565 - Noninvasive miniaturized mass-flow meter using a curved cannula for implantable axial f... 17364215 - Importance and interpretation of fast-response airway hygrometry during ventilation of ... 1537975 - Blood and injection phobia: background and cognitive, physiological, and behavioral var... 1662765 - Complete reversion of the abo phenotype in d. melanogaster occurs only when the blood t... 626525 - Oxidative metabolism in cord-blood polymorphonuclear leucocytes. 2059405 - Cerebral blood flow and metabolism studies in multi-infarct dementia. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 37 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-23 Completed Date: 2011-11-18 Revised Date: 2012-02-23 |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 900-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Joint Department of Biomedical Engineering, University of North Carolina-North Carolina State University, Chapel Hill, NC 27599, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity / physiology Contrast Media Image Enhancement / methods* Kidney / blood supply, physiology*, ultrasonography* Male Microbubbles Perfusion Imaging / methods* Rats Rats, Sprague-Dawley Renal Circulation / physiology* Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
|
HL-02334/HL/NHLBI NIH HHS; R01 HL002334-54A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive assessment of atherosclerosis in apolipoprotein-e knockout mice by ultrasound biomicrosc...
Next Document: Real-Time Passive Acoustic Monitoring of HIFU-Induced Tissue Damage.