| Validation of an automated technique for determining the mechanical characteristics of coronary arteries during balloon angioplasty: laboratory assessment with necropsy segments. | |
| | |
MedLine Citation:
|
PMID: 10078091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To develop a technique for automatic inflation of a percutaneous transluminal coronary angioplasty (PTCA) balloon, with continuous measurement of the balloon pressure and volume; to validate the technique for determining the mechanical characteristics of coronary arteries. METHODS: During necropsy examination of the hearts of nine patients, 17 coronary artery samples were obtained for histological examination. A PTCA balloon was inserted into each artery, and the balloon pressure and volume were measured continuously during four repeat automatic inflations of the balloon. RESULTS: Of the 17 arteries, eight showed elastic, six plastic, and three fracture pressure-volume deformation characteristics. For the plastic deformations, the first inflation required a higher pressure than subsequent repeat inflations of 82 (61) kPa (mean (SD), range 25 to 175 kPa). For the three in the fracture group, the pressure drop because of the fracture occurred between 210 and 540 kPa. Two of these three showed a tear on visual inspection, and the other showed disruption of the intimal plaque on blinded histological examination. Of the six with plastic deformation characteristics alone, one showed a tear, and on histological examination two others showed splitting of the internal and external elastic lamina and one showed separation of intima and media. None in the elastic group showed any of these characteristics. CONCLUSIONS: Plastic and fracture deformation characteristics could be differentiated from elastic characteristics. Visual or histological evidence of fracturing was present in all three arteries identified during angioplasty as having pressure-volume fracture characteristics. |
| | |
Authors:
|
A Murray; V Allen; M K Bennett |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 79 ISSN: 1355-6037 ISO Abbreviation: Heart Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 608-12 Citation Subset: AIM; IM |
Affiliation:
|
Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary
/
adverse effects,
methods* Arteries / injuries, physiopathology Coronary Disease / physiopathology, therapy* Coronary Vessels / injuries, physiopathology* Elasticity Humans Intraoperative Period Pressure |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Minimally invasive aortic valve replacement through a transverse sternotomy: a word of caution.
Next Document: Evaluation of technician supervised treadmill exercise testing in a cardiac chest pain clinic.