Document Detail

Validation of the archimedes diabetes model.
MedLine Citation:
PMID:  14578246     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To validate the Archimedes model of diabetes and its complications for a variety of populations, organ systems, treatments, and outcomes. RESEARCH DESIGN AND METHODS: We simulated a variety of randomized controlled trials by repeating in the model the steps taken for the real trials and comparing the results calculated by the model with the results of the trial. Eighteen trials were chosen by an independent advisory committee. Half the trials had been used to help build the model ("internal" or "dependent" validations); the other half had not. Those trials comprise "external" or "independent" validations. RESULTS: A total of 74 validation exercises were conducted involving different treatments and outcomes in the 18 trials. For 71 of the 74 exercises there were no statistically significant differences between the results calculated by the model and the results observed in the trial. Considering only the trials that were never used to help build the model-the independent or external validations-the correlation was r = 0.99. Including all of the exercises, the correlation between the outcomes calculated by the model and the outcomes seen in the trials was r = 0.99. When the absolute differences in outcomes between the control and treatment groups were compared, the correlation coefficient was r = 0.97. CONCLUSIONS: The Archimedes diabetes model is a realistic representation of the anatomy, pathophysiology, treatments, and outcomes pertinent to diabetes and its complications for applications that involve the populations, treatments, outcomes, and health care settings spanned by the trials.
David M Eddy; Leonard Schlessinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Diabetes care     Volume:  26     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-27     Completed Date:  2004-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3102-10     Citation Subset:  IM    
Care Management Institute, Kaiser Permanente and Kaiser Permanente Southern California, Oakland, California, USA.
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MeSH Terms
Clinical Trials as Topic
Computer Simulation
Diabetes Mellitus, Type 1 / drug therapy*,  physiopathology*
Diabetes Mellitus, Type 2 / drug therapy*,  physiopathology*
Hypoglycemic Agents / therapeutic use*
Models, Biological*
Reproducibility of Results
Reg. No./Substance:
0/Hypoglycemic Agents
Comment In:
Diabetes Care. 2003 Nov;26(11):3168-71   [PMID:  14578256 ]
Diabetes Care. 2003 Nov;26(11):3182-3   [PMID:  14578260 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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