Document Detail

Validation of airflow perturbation device resistance measurements in excised sheep lungs.
MedLine Citation:
PMID:  15253119     Owner:  NLM     Status:  MEDLINE    
The airflow perturbation device (APD) is a recently redesigned instrument to measure resistance in the respiratory system. The APD is small and easy to use, gives rapid resistance measurements, and can easily separate inhalation from exhalation components. It also possesses some operational characteristics similar to forced oscillation (FO). Excised sheep lungs within a respiratory chamber were used to determine the effective resistance domain of the APD. Retrograde catheters were installed in the airways, alveolar capsules were used to measure alveolar pressures, and chamber pressure was used as pleural pressure. FO measurements were made to compare with the APD. The APD was found to give a resistance measurement about 1.7 to 1.9 times airway resistance. FO gave a resistance measurement 1.4 times airway resistance. Resistance values differed depending on analysis procedure and frequency of oscillation. Both devices were found to produce oscillations beyond the pleural surface of the lungs. It was concluded that the APD and FO measure similar respiratory resistances.
Arthur T Johnson; Manjit S Sahota
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; In Vitro; Journal Article; Validation Studies    
Journal Detail:
Title:  Physiological measurement     Volume:  25     ISSN:  0967-3334     ISO Abbreviation:  Physiol Meas     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2005-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  679-90     Citation Subset:  IM    
Biological Resources Engineering, University of Maryland, College Park, MD 20742-2315, USA.
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MeSH Terms
Airway Resistance / physiology*
Forced Expiratory Flow Rates / physiology*
Reproducibility of Results
Respiratory Function Tests / methods
Respiratory Mechanics / physiology*
Sensitivity and Specificity

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