Document Detail

Validation study on the accuracy of echocardiographic measurements of right ventricular systolic function in pulmonary hypertension.
MedLine Citation:
PMID:  22230250     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The accuracy of echocardiographic parameters of right ventricular (RV) function has not been sufficiently validated in patients with pulmonary hypertension (PH). The aim of this study was to evaluate whether echocardiographic measurements reliably reflect RV systolic function in PH using cardiac magnetic resonance imaging (CMRI)-derived RV ejection fraction (RVEF) as a gold standard.
METHODS: A total of 37 consecutive patients with PH, 20 with pulmonary arterial hypertension, 12 with chronic thromboembolic PH, and five others, were prospectively studied. All patients underwent echocardiography, CMRI, and right-heart catheterization within a 1-week interval. Associations between five echocardiography-derived parameters of RV systolic function and CMRI-derived RVEF were evaluated.
RESULTS: All five echocardiography-derived parameters were significantly correlated with CMRI-derived RVEF (percentage RV fractional shortening: r = 0.48, P = .0011; percentage RV area change: r = 0.40, P = .0083; tricuspid annular plane systolic excursion [TAPSE]: r = 0.86, P < .0001; RV myocardial performance index: r = -0.59, P < .0001; and systolic lateral tricuspid annular motion velocity: r = 0.63, P < .0001). Compared with the other indices, TAPSE exhibited the highest correlation coefficient. Of the five echocardiographic measurements, only TAPSE significantly predicted CMRI-derived RVEF in multiple regression analysis (P < .0001). Intraobserver and interobserver reproducibility was favorable for all five indices and was particularly high for TAPSE and systolic lateral tricuspid annular motion velocity.
CONCLUSIONS: Echocardiographic measurements are promising noninvasive indices of RV systolic function in patients with PH. In particular, TAPSE is superior to other indices in accuracy.
Takahiro Sato; Ichizo Tsujino; Hiroshi Ohira; Noriko Oyama-Manabe; Asuka Yamada; Yoichi M Ito; Chisa Goto; Taku Watanabe; Shinji Sakaue; Masaharu Nishimura
Publication Detail:
Type:  Journal Article; Validation Studies     Date:  2012-01-09
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  25     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-06-28     Revised Date:  2012-08-22    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  280-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
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MeSH Terms
Echocardiography / instrumentation*
Heart Ventricles / drug effects,  ultrasonography*
Hypertension, Pulmonary / pathology,  ultrasonography*
Magnetic Resonance Imaging, Cine / instrumentation
Middle Aged
Regression Analysis
Reproducibility of Results
Statistics as Topic
Stroke Volume / physiology
Ventricular Function, Right / physiology*
Comment In:
J Am Soc Echocardiogr. 2012 Jul;25(7):804   [PMID:  22607886 ]

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