| Validation of SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score for prediction of outcomes after unprotected left main coronary revascularization. | |
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MedLine Citation:
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PMID: 20630454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study aimed to validate the SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score representing angiographic complexity after unprotected left main coronary artery (ULMCA) revascularization. BACKGROUND: The validity of the SYNTAX score has been adequately evaluated. METHODS: The SYNTAX scores were calculated for 1,580 patients in a large multicenter registry who underwent percutaneous coronary intervention (PCI) (n = 819) or coronary artery bypass graft (CABG) (n = 761) for ULMCA stenosis. The outcomes of interests were 3-year incidences of major adverse vascular events (MAVE), including death, Q-wave myocardial infarction, and stroke and major adverse cardiac and cerebrovascular events (MACCE), including MAVE and target vessel revascularization of ULMCA. RESULTS: The incidence of 3-year MAVE was 6.2% in the lowest (< or =23), 7.1% in the intermediate (23 to approximately 36), and 17.4% in the highest (>36) SYNTAX score tertile groups after PCI (p = 0.010). However, the incidences of MAVE in the CABG group and MACCE in the PCI and CABG groups did not differ among the SYNTAX tertiles. In subgroups, the MAVE (p = 0.005) and MACCE (p = 0.007) rates according to the SYNTAX score tertiles were significantly different in patients receiving drug-eluting stent, not in those receiving bare-metal stent. When compared with the clinical EuroSCORE (European System for Cardiac Operative Risk Evaluation), the C-indexes of SYNTAX score and EuroSCORE were 0.59 and 0.67, respectively, for discrimination of MAVE and 0.53 and 0.57, respectively, for MACCE. CONCLUSIONS: The angiographic SYNTAX score seems to play a partial role in predicting long-term adverse events after PCI for ULMCA stenosis. A complementary consideration of patient's clinical risk might improve the predictive ability of risk score. |
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Authors:
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Young-Hak Kim; Duk-Woo Park; Won-Jang Kim; Jong-Young Lee; Sung-Cheol Yun; Soo-Jin Kang; Seung-Whan Lee; Cheol Whan Lee; Seong-Wook Park; Seung-Jung Park |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Validation Studies |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 3 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-11-02 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 612-23 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, Center for Medical Research and Information, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary / adverse effects, instrumentation*, mortality Cardiovascular Agents / administration & dosage* Cerebrovascular Disorders / etiology Coronary Angiography Coronary Artery Bypass* / adverse effects, mortality Coronary Stenosis / mortality, radiography, surgery, therapy* Drug-Eluting Stents* Female Health Status Indicators* Humans Kaplan-Meier Estimate Male Middle Aged Myocardial Infarction / etiology Paclitaxel / administration & dosage* Predictive Value of Tests Proportional Hazards Models Prosthesis Design Registries Reproducibility of Results Republic of Korea Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 33069-62-4/Paclitaxel |
| Comments/Corrections | |
Comment In:
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JACC Cardiovasc Interv. 2010 Jun;3(6):642-7
[PMID:
20630457
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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