| Validation of noninvasive measurements of cardiac output in mice using echocardiography. | |
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MedLine Citation:
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PMID: 21315557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although multiple echocardiographic methods exist to calculate cardiac output (CO), they have not been validated in mice using a reference method. METHODS: Echocardiographic and flow probe measurements of CO were obtained in mice before and after albumin infusion and inferior vena cava occlusions. Echocardiography was also performed before and after endotoxin injection. Cardiac output was calculated using left ventricular volumes obtained from an M-mode or a two-dimensional view, left ventricular stroke volume calculated using the pulmonary flow, or estimated by the measurement of pulmonary velocity time integral (VTI). RESULTS: Close correlations were demonstrated between flow probe-measured CO and all echocardiographic measurements of CO. All echocardiographic-derived CO overestimated the flow probe-measured CO. Two-dimensional image-derived CO was associated with the smallest overestimation of CO. Interobserver variability was lowest for pulmonary VTI-derived CO. CONCLUSION: In mice, CO calculated from two-dimensional parasternal long-axis images is most accurate when compared with flow probe measurements; however, pulmonary VTI-derived CO is subject to less variability. |
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Authors:
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François Tournoux; Bodil Petersen; Hélène Thibault; Lin Zou; Michael J Raher; Baptiste Kurtz; Elkan F Halpern; Miguel Chaput; Wei Chao; Michael H Picard; Marielle Scherrer-Crosbie |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2011-02-18 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 24 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-07-26 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 465-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Ultrasound Cardiac Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Analysis of Variance Animals Cardiac Output* Disease Models, Animal Echocardiography / methods* Endotoxins / pharmacology Hemodynamics Male Mice Mice, Inbred C57BL |
| Grant Support | |
ID/Acronym/Agency:
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1S10RR022586-01A1/RR/NCRR NIH HHS; R01 GM080906-05/GM/NIGMS NIH HHS; S10 RR022586-01A1/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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