Document Detail

Validation of the NINCDS-ADRDA criteria regarding gait in the clinical diagnosis of Alzheimer disease. A clinicopathologic study.
MedLine Citation:
PMID:  8534414     Owner:  NLM     Status:  MEDLINE    
The NINCDS-ADRDA criteria for the clinical diagnosis of probable Alzheimer disease (AD) state that "gait disturbances at the onset or very early in the course of the illness make the diagnosis of Alzheimer disease uncertain or unlikely," yet there have been few studies documenting the validity of the statement. We therefore reviewed all cases of pure autopsy-proven AD in the Ramsey Brain Bank to determine how frequently an abnormal gait was noted at time of presentation. Any reported gait disturbance was considered an abnormal gait. Only cases for which medical records were available documenting the patient's presentation for dementia were included. Cases were excluded if any other pathology was present that may have contributed to the patient's dementia or to a gait disorder, if neuroleptic medication had been used, or if there was a preexisting gait disorder. Clinical dementia severity at time of presentation was graded as mild, moderate, or severe per DSM-IIIR criteria. Of the 95 cases that met study criteria, none of the 36 patients with mild dementia were reported to have had an abnormal gait. Sixteen percent of the patients with moderate and 32% with severe dementia had gait abnormalities reported. This study confirms the statement regarding gait in the NINCDS-ADRDA criteria.
T A Ala; W H Frey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  9     ISSN:  0893-0341     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-07     Completed Date:  1996-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul-Ramsey Medical Center, Minnesota 55101-2595, USA.
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MeSH Terms
Age of Onset
Aged, 80 and over
Alzheimer Disease / diagnosis*
Dementia / diagnosis
Diagnosis, Differential
Pathology, Clinical
Psychiatric Status Rating Scales

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