| Validation of My Family Health Portrait for six common heritable conditions. | |
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MedLine Citation:
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PMID: 20479646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the ability of My Family Health Portrait to accurately collect family history for six common heritable disorders. BACKGROUND: Family history is useful to assess disease risk but is not widely used. We compared the pedigree from My Family Health Portrait, an online tool for collection of family history, to a pedigree supplemented by a genetics professional. METHODS: One hundred fifty volunteers collected their family histories using My Family Health Portrait. A genetic counselor interviewed the volunteers to validate the entries and add diagnoses, as needed. The content and the affection assignments of the pedigrees were compared. The pedigrees were entered into Family Healthware to assess risks for the diseases. RESULTS: The sensitivity of My Family Health Portrait varied among the six diseases (67-100%) compared to the supplemented pedigree. The specificities ranged from 92 to 100%. When the pedigrees were used to generate risk scores, My Family Health Portrait yielded identical risks to the supplemented pedigree for 94-99% of the volunteers for diabetes and colon, breast, and ovarian cancer. The agreement was lower for coronary artery disease (68%) and stroke (83%). CONCLUSIONS: These data support the validity of My Family Health Portrait pedigrees for four common conditions--diabetes and colon, breast, and ovarian cancer. The tool performed less well for coronary artery disease and stroke. We recommend that the tool be improved to better capture information for these two common conditions. |
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Authors:
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Flavia M Facio; W Gregory Feero; Amy Linn; Neal Oden; Kandamurugu Manickam; Leslie G Biesecker |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Validation Studies |
Journal Detail:
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Title: Genetics in medicine : official journal of the American College of Medical Genetics Volume: 12 ISSN: 1530-0366 ISO Abbreviation: Genet. Med. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-14 Revised Date: 2012-01-18 |
Medline Journal Info:
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Nlm Unique ID: 9815831 Medline TA: Genet Med Country: United States |
Other Details:
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Languages: eng Pagination: 370-5 Citation Subset: IM |
Affiliation:
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National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. ffacio@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Disease / genetics* Diabetes Mellitus / genetics* Family Health* Female Genetic Predisposition to Disease* Humans Male Medical History Taking Middle Aged Neoplasms / genetics* Pedigree |
| Grant Support | |
ID/Acronym/Agency:
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ZIA HG200359-04/HG/NHGRI NIH HHS |
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