Document Detail

Validation of the Hopkins telephone diagnostic interview for restless legs syndrome.
MedLine Citation:
PMID:  17644424     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Because the diagnosis of restless legs syndrome (RLS) depends on clinical features ascertained by interview, it is important to have structured diagnostic instruments that can guide a diagnostician to an accurate diagnosis. With this aim in mind, the RLS Center at Johns Hopkins has been developing the Hopkins telephone diagnostic interview (HTDI). A previous validation was performed on a patient group. In the current report, we have extended that validation to a non-patient group drawn from on ongoing family study. METHODS: Family members from a case-control RLS study were diagnosed by telephone. Once all available family members in a given family had been interviewed, those who lived locally and had responded were asked to come to Johns Hopkins-Bayview Medical center and had dual clinical interviews to ascertain RLS diagnosis. We then compared the results between the two clinical interviews and between the HTDI and the clinical interviews. RESULTS: Diagnostic agreement between two expert clinicians was 93-96% (kappa 0.87-0.92). Compared to those subjects on whom the clinicians agreed, the HTDI agreed at least 90% of the time; sensitivity was at least 0.90, specificity 0.91, positive predictive value 0.86, and negative predictive value 0.94. CONCLUSION: The HTDI managed a high level of diagnostic accuracy, showing only slightly less agreement than the two clinical interviewers. Because of a mean 12-month period between HTDI and clinical interview, this result also indicates that the subjects' reports of symptoms are consistent and stable. The HTDI should be useful for confirming questionnaire diagnoses or screening subjects to enter basic or therapeutic trials.
Wayne A Hening; Richard P Allen; Mystinna Washburn; Suzanne Lesage; Christopher J Earley
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Publication Detail:
Type:  Journal Article     Date:  2007-07-17
Journal Detail:
Title:  Sleep medicine     Volume:  9     ISSN:  1389-9457     ISO Abbreviation:  Sleep Med.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
RLS Center, Asthma & Allergy, SBTBLJH Bayview, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
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MeSH Terms
Case-Control Studies
Diagnosis, Differential
Hospitals, University
Interviews as Topic*
Middle Aged
Observer Variation
Restless Legs Syndrome / diagnosis*,  epidemiology,  genetics
Sensitivity and Specificity

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