| Validation of estimated renal function measurements compared with the isotopic glomerular filtration rate in an HIV-infected cohort. | |
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MedLine Citation:
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PMID: 20887753 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We performed a cross-sectional study to determine the best method for estimating the glomerular filtration rate (GFR) in HIV-infected subjects. Isotopic GFR was correlated with 24-h urine creatinine clearance, cystatin C levels, and 3 creatinine-based equations-the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)-in 15 patients. Cystatin C showed the strongest correlation with isotopic GFR (r=-0.760, p=0.001). When cystatin C was used as the reference variable for all 106 patients, CKD-EPI proved to be superior to the other equations (r=-0.671, p<0.001). Time with HIV infection, unsuppressed viral load, low CD4 T-cell counts, and use of protease inhibitors are related to an increased risk of renal impairment, leading us to recommend early initiation of antiretroviral therapy accompanied by a regular renal study. |
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Authors:
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Anna Bonjoch; Beatriz Bayés; Joaquim Riba; Jordi Puig; Carla Estany; Núria Perez-Alvarez; Bonaventura Clotet; Eugènia Negredo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-29 |
Journal Detail:
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Title: Antiviral research Volume: 88 ISSN: 1872-9096 ISO Abbreviation: Antiviral Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 347-54 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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University Hospital Germans Trias, Barcelona, Spain. abonjoch@flsida.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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