| Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. | |
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MedLine Citation:
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PMID: 21084417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the results obtained by using numerical flow simulations with the results of combined single photon emission computed tomography (SPECT) and computed tomography (CT) and to demonstrate the importance of correct boundary conditions for the numerical methods to account for the large amount of interpatient variability in airway geometry. MATERIALS AND METHODS: This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined. RESULTS: Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD. CONCLUSION: This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100322/-/DC1. |
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Authors:
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Jan W De Backer; Wim G Vos; Samir C Vinchurkar; Rita Claes; Anton Drollmann; Denis Wulfrank; Paul M Parizel; Paul Germonpré; Wilfried De Backer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 854-62 Citation Subset: AIM; IM |
Copyright Information:
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© RSNA, 2010 |
Affiliation:
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FluidDA, Groeningenlei 132, 2550 Kontich, Belgium. Jan.DeBacker@FluidDA.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols / administration & dosage Aged Asthma / physiopathology, radiography*, radionuclide imaging* Female Humans Male Middle Aged Models, Anatomic Radiographic Image Interpretation, Computer-Assisted Radiopharmaceuticals / administration & dosage Respiratory Function Tests Software Technetium Tc 99m Pentetate / administration & dosage Tomography, Emission-Computed, Single-Photon* Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Radiopharmaceuticals; 65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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