| Validation of CT attenuation correction for high-speed myocardial perfusion imaging using a novel cadmium-zinc-telluride detector technique. | |
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MedLine Citation:
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PMID: 20847159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Sixty-six patients (body mass index ± SD, 27.2 ± 3.5 kg/m(2); range, 19.1-36.0 kg/m(2)) underwent a 1-d (99m)Tc-tetrofosmin adenosine stress-rest imaging protocol with 15-min acquisitions on a standard dual-head SPECT camera. All scans were repeated within minutes on the CZT camera, with 3-min acquisitions for stress (low dose) and 2-min acquisitions for rest (high dose) as recently established. We compared maximum myocardial uptake (20-segment model) from CZT versus standard SPECT MPI by intraclass correlation without and with CT AC. In addition, clinical agreement for each coronary territory for all scans from both devices was assessed, and Bland-Altmann (BA) limits of agreement for percentage uptake were calculated. RESULTS: The clinical agreement between CZT and standard SPECT cameras was 96% for noncorrected low- and high-dose images (r = 0.90 and BA = -18 to 15, and r = 0.91 and BA = -15 to 16, respectively), and agreement after AC was 96% for low- and 99% for high-dose images (r = 0.87 and BA = -16 to 14, and r = 0.88 and BA = -16 to 14, respectively). CONCLUSION: Our results support that AC of MPI on the novel CZT camera, compared with AC MPI on a conventional SPECT camera, is feasible because it provides a high correlation of segmental tracer uptake and an excellent clinical agreement. |
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Authors:
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Bernhard A Herzog; Ronny R Buechel; Lars Husmann; Aju P Pazhenkottil; Irene A Burger; Mathias Wolfrum; Rene N Nkoulou; Ines Valenta; Jelena R Ghadri; Valerie Treyer; Philipp A Kaufmann |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-09-16 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1539-44 Citation Subset: IM |
Affiliation:
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Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cadmium Compounds* Equipment Design Equipment Failure Analysis Female Humans Male Middle Aged Myocardial Perfusion Imaging / methods* Radiographic Image Enhancement / methods* Reproducibility of Results Sensitivity and Specificity Tellurium* Tomography, X-Ray Computed / methods* Transducers* Zinc* |
| Chemical | |
Reg. No./Substance:
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0/Cadmium Compounds; 1306-25-8/cadmium telluride; 13494-80-9/Tellurium; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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