Document Detail


Validation of the CDC biofilm reactor as a dynamic model for assessment of encrustation formation on urological device materials.
MedLine Citation:
PMID:  20091909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Contemporary medical science is reliant upon the rational selection and utilization of devices, and therefore, an increasing need has developed for in vitro systems aimed at replicating the conditions to which urological devices will be subjected to during their use in vivo. We report the development and validation of a novel continuous flow encrustation model based on the commercially available CDC biofilm reactor. Proteus mirabilis-induced encrustation formation on test biomaterial sections under varying experimental parameters was analyzed by X-ray diffraction, infrared- and Raman spectroscopy and by scanning electron microscopy. The model system produced encrusted deposits similar to those observed in archived clinical samples. Results obtained for the system are highly reproducible with encrustation being rapidly deposited on test biomaterial sections. This model will have utility in the rapid screening of encrustation behavior of biomaterials for use in urological applications.
Authors:
Brendan F Gilmore; Turlough M Hamill; David S Jones; Sean P Gorman
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Publication Detail:
Type:  In Vitro; Journal Article; Validation Studies    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  93     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-40     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, BT9 7BL, UK. b.gilmore@qub.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Bacterial Adhesion
Biocompatible Materials
Biofilms*
Bioreactors
Equipment Contamination*
Humans
Materials Testing
Microscopy, Electron, Scanning
Models, Biological*
Proteus mirabilis / growth & development*
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
Urinary Catheterization
Urology / instrumentation*
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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