| Validation of 3D echocardiographic assessment of left ventricular volumes, mass, and ejection fraction in neonates and infants with congenital heart disease: a comparison study with cardiac MRI. | |
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MedLine Citation:
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PMID: 20855861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: quantitative assessment and validation of left ventricular (LV) volumes and mass in neonates and infants with complex congenital heart disease (CHD) is important for clinical management but has not been undertaken. We compared matrix-array 3D echocardiography (3D echo) measurements of volumes, mass, and ejection fraction (EF) with those measured by cardiac MRI in young patients with CHD and small LVs because of either young age or LV hypoplasia. METHODS AND RESULTS: thirty-five patients aged <4 years (median, 0.8 years) undergoing MRI were prospectively enrolled. Three-dimensional echo was acquired immediately after MRI, and volume, mass, and EF measurements, using summation of discs methodology, were compared with MRI. Three-dimensional echo end-diastolic volume (24.4±15.7 versus 24.8±46.4 mL; P=0.01; intraclass correlation coefficient [ICC], 0.96) and end-systolic volume (12.3±8.6 versus 9.6±6.8 mL; P<0.001; ICC, 0.90) correlated with MRI with small mean differences (-0.49 mL [P=0.6] and 2.7 mL [P=0.001], respectively). Three-dimensional echo EF was smaller than MRI by 9.3% (P<0.001), and 3D echo LV mass measurements were comparable to MRI (17.3±10.3 versus 17.6±12 g; P<0.77; ICC, 0.93), with a small mean difference (1.1 g; P=0.28). There was good intra- and interobserver reliability for all measurements. CONCLUSIONS: in neonates and infants with CHD and small LVs (age appropriate or hypoplastic), matrix-array 3D echo measurements of mass and volumes compare well with MRI, providing an important modality for ventricular size and performance analysis in these patients, particularly in those with left-side heart obstructive lesions. |
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Authors:
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Mark K Friedberg; Xioahong Su; Wayne Tworetzky; Brian D Soriano; Andrew J Powell; Gerald R Marx |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-09-20 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 3 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-23 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 735-42 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Echocardiography, Three-Dimensional / methods, standards* Heart Defects, Congenital / pathology, ultrasonography* Heart Ventricles / pathology, ultrasonography* Humans Infant Infant, Newborn Magnetic Resonance Imaging / methods* Observer Variation Organ Size Prospective Studies Reproducibility of Results Stroke Volume* |
| Comments/Corrections | |
Erratum In:
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Circ Cardiovasc Imaging. 2011 Mar 1;4(2):e4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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