Document Detail

Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.
MedLine Citation:
PMID:  21586440     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA).
OBJECTIVE: To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the Visser decision rule.
METHODS: 455 patients with early arthritis were studied. The diagnostic performance of the criteria was evaluated using methotrexate treatment within 1 year, expert opinion RA and erosive disease as 'gold standards'. Erosive disease was defined as a 0-3 year change in radiographic score of ≥5.
RESULTS: The discriminative ability of the three criteria sets (2010 ACR/EULAR, 1987 ACR criteria and Visser algorithm) was similar with areas under the curve of 0.71-0.78 ('gold standard' methotrexate), 0.74-0.80 (gold standard expert opinion RA) and 0.63-0.67 (gold standard erosive disease after 3 years). The sensitivity of the 2010 ACR/EULAR criteria was highest with 0.85 (gold standard methotrexate). 86% of patients with RA and 51% of 'non-RA' patients according to the new criteria used methotrexate.
CONCLUSION: The 2010 ACR/EULAR criteria were slightly more sensitive, but otherwise performed similarly to the older criteria. A high percentage of 'non-RA' patients used methotrexate, the gold standard for RA. The ability of the new criteria to identify patients with erosive disease was low, possibly owing to the effect of intensive treatment.
Karin Britsemmer; Jennie Ursum; Martijn Gerritsen; L H van Tuyl; Lilian van Tuyl; Dirkjan van Schaardenburg
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2011-05-17
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  70     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-06-30     Completed Date:  2011-11-18     Revised Date:  2011-12-09    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1468-70     Citation Subset:  IM    
Department of Rheumatology, Jan van Breemen Research Institute I Reade, Amsterdam, The Netherlands.
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MeSH Terms
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / drug therapy,  radiography*
Disease Progression
Early Diagnosis
Follow-Up Studies
Methotrexate / therapeutic use
Middle Aged
Severity of Illness Index*
Young Adult
Reg. No./Substance:
0/Antirheumatic Agents; 59-05-2/Methotrexate
Erratum In:
Ann Rheum Dis. 2011 Nov;70(11):2060
Note: van Tuyl, Lilian [corrected to van Tuyl, L H]

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